Roy Roopali, Zhang Bo, Moses Marsha A
Vascular Biology Program and Department of Surgery, Children's Hospital Boston, MA 02115-5737, USA.
Exp Cell Res. 2006 Mar 10;312(5):608-22. doi: 10.1016/j.yexcr.2005.11.022. Epub 2006 Jan 24.
Angiogenesis is an integral element of normal physiologic development as well as of wound healing and a variety of pathologic conditions. Since the earliest studies of the cellular processes required for the formation of new capillaries from preexisting vessels, proteolysis has been recognized as one of the earliest and most sustained activities involved in these events. Several proteases including matrix metalloproteases (MMPs), and the closely related ADAM (a disintegrin and metalloprotease domain) and ADAMTS (a disintegrin and metalloprotease domain with thrombospondin motifs) families, as well as cysteine and serine proteases, have been implicated in this regulation. The current review addresses the contribution of these proteases in the positive and negative regulation of angiogenesis as mediated by degradation of the endothelial basement membrane and extracellular matrix proteins, release of angiogenic factors, processing of cytokines, growth factors and growth factor receptors, and the production of endogenous inhibitors.
血管生成是正常生理发育、伤口愈合及多种病理状况不可或缺的一部分。自最早对从已有血管形成新毛细血管所需细胞过程进行研究以来，蛋白水解作用就被认为是这些事件中最早且持续时间最长的活动之一。包括基质金属蛋白酶（MMPs）、密切相关的ADAM（一种去整合素和金属蛋白酶结构域）和ADAMTS（一种具有血小板反应蛋白基序的去整合素和金属蛋白酶结构域）家族以及半胱氨酸和丝氨酸蛋白酶在内的几种蛋白酶都参与了这一调节过程。本综述探讨了这些蛋白酶在内皮基底膜和细胞外基质蛋白降解、血管生成因子释放、细胞因子加工、生长因子和生长因子受体处理以及内源性抑制剂产生所介导的血管生成的正负调节中的作用。
