Siminiak Tomasz, Fiszer Dorota, Jerzykowska Olga, Grygielska Beata, Kałmucki Piotr, Kurpisz Maciej
University School of Medical Sciences, Department of Cardiology, District Hospital, Poznań, Poland.
Kardiol Pol. 2003 Dec;59(12):492-501.
Numerous animal experimental studies as well as the initial human experience have shown that autologous skeletal myoblast transplantation into area of post-infarction left ventricular injury results in an increase in segmental contractile performance related to contraction of cells differentiated from transplanted myoblasts. We have previously introduced skeletal myoblast transplantation performed at the time of coronary artery bypass grafting. Currently, we report the first two cases in Poland of percutaneous autologous myoblast transplantation in the treatment of post-infarction heart failure. The procedures were performed using a catheter system enabling intra-myocardial injections from the lumen of cardiac veins under intravascular ultrasound guidance. Lack of major procedural complications and expected benefits from myocardial regeneration in patients with post-infarction heart failure justify initiation of phase one clinical trial to evaluate this method.
大量动物实验研究以及最初的人体试验经验表明，将自体骨骼肌成肌细胞移植到梗死后期左心室损伤区域，会使与移植成肌细胞分化而来的细胞收缩相关的节段性收缩性能增强。我们之前曾介绍过在冠状动脉搭桥手术时进行的骨骼肌成肌细胞移植。目前，我们报告波兰首例两例经皮自体成肌细胞移植治疗心肌梗死后心力衰竭的病例。手术采用导管系统，在血管内超声引导下从心静脉腔进行心肌内注射。在心肌梗死后心力衰竭患者中，缺乏主要手术并发症以及心肌再生带来的预期益处，证明启动一期临床试验以评估该方法是合理的。
