Huang Zei-Shung, Chien Kuo-Liong, Yang Chi-Yu, Wang Chiu-Hwa, Chang Tien-Chun, Chen Chien-Jen
Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
J Formos Med Assoc. 2003 Nov;102(11):775-81.
A higher total leukocyte count has been reported to predict all-cause mortality in men, but data are limited for this relation in women and for the relation between differential leukocyte counts and all-cause mortality in both men and women. This study was designed to analyze these relationships in Taiwanese.
A total of 8447 subjects were enrolled from participants in a physical check-up program at National Taiwan University Hospital from 1995 to 1997. Information on mortality was obtained from a national mortality databank that was updated to the end of 2001. Data were analyzed by Student's t test and Cox regression analysis.
Among the 245 deaths, 88 were due to cancer and 62 were due to cardiovascular diseases. Cox regression analysis revealed an inverse association between lymphocyte count and all-cause mortality in the study group as a whole (all subjects, p < 0.01, hazard ratio = 0.73). This inverse association was mainly due to an inverse association between lymphocyte count and cancer mortality (p < 0.05, hazard ratio = 0.64), especially the mortality from hepatoma (p = 0.010, hazard ratio = 0.29). The latter hazard ratio of 0.29 indicates that, in all subjects, every decrease of 1.0 x 10(9)/L in lymphocyte count increased the risk of mortality from hepatoma by 3.45-fold during an average follow-up period of 65.5 months. There was a positive association between total leukocyte count and all-cause mortality in men (p < 0.05, hazard ratio = 1.10), mainly due to both the neutrophil and monocyte counts having positive associations with the cardiovascular mortality (both p < 0.05, hazard ratio = 1.23 and 1.22, respectively). The latter hazard ratio of 1.22 indicates that, in men, every increase of 0.1 x 10(9)/L in monocyte count increased the risk of cardiovascular mortality by 1.22-fold.
In Taiwanese adults of both genders, a lower lymphocyte count is associated with cancer mortality, especially mortality from hepatoma. In Taiwanese men, higher neutrophil and monocyte counts are associated with cardiovascular mortality.
据报道，较高的白细胞总数可预测男性的全因死亡率，但关于女性中这种关系以及男性和女性白细胞分类计数与全因死亡率之间关系的数据有限。本研究旨在分析台湾人群中的这些关系。
从1995年至1997年在台湾大学医院参加体检项目的参与者中总共招募了8447名受试者。死亡信息来自更新至2001年底的国家死亡率数据库。数据采用学生t检验和Cox回归分析。
在245例死亡病例中，88例死于癌症，62例死于心血管疾病。Cox回归分析显示，在整个研究组（所有受试者）中，淋巴细胞计数与全因死亡率呈负相关（p < 0.01，风险比 = 0.73）。这种负相关主要是由于淋巴细胞计数与癌症死亡率呈负相关（p < 0.05，风险比 = 0.64），尤其是肝癌死亡率（p = 0.010，风险比 = 0.29）。后一个风险比0.29表明，在所有受试者中，在平均65.5个月的随访期内，淋巴细胞计数每降低1.0×10⁹/L，肝癌死亡风险增加3.45倍。男性的白细胞总数与全因死亡率呈正相关（p < 0.05，风险比 = 1.10），主要是因为中性粒细胞和单核细胞计数均与心血管死亡率呈正相关（均p < 0.05，风险比分别为1.23和1.22）。后一个风险比1.22表明，在男性中，单核细胞计数每增加0.1×10⁹/L，心血管死亡风险增加1.22倍。
在台湾成年男女中，较低的淋巴细胞计数与癌症死亡率相关，尤其是肝癌死亡率。在台湾男性中，较高的中性粒细胞和单核细胞计数与心血管死亡率相关。
