Gosav Evelina Maria, Tanase Daniela Maria, Buliga-Finis Oana Nicoleta, Rezuș Ioana-Irina, Morariu Paula Cristina, Floria Mariana, Rezus Ciprian
Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iasi, Romania.
Life (Basel). 2024 Aug 7;14(8):985. doi: 10.3390/life14080985.
Given the continuous changes in the world, with an increasing trend of unhealthy lifestyles, metabolic comorbidities, and increased susceptibility to cardiovascular diseases (CVDs), researchers change their attention to improve not only the therapeutic platform but also current CVD predictive and prognostic tools to improve disease outcomes. As CVD is characterized by an inflammatory paradigm involving, to some degree, the innate and adaptative immune systems, the neutrophil-to-lymphocyte ratio (NLR) emerged as a potential low-cost, rapidly available, and reliable inflammatory marker, with substantial recent evidence showing its potential utility in clinical practice. Thus, in this literature review, we will present an up-to-date discussion of the prognostic role of NLR in the most frequent CVDs, such as acute and chronic coronary disease, atherosclerotic disease, heart failure, cardiac valvopathies, and cardiac arrhythmias with predilection to atrial fibrillation.
鉴于世界形势不断变化，不健康生活方式的趋势日益增加、代谢合并症以及心血管疾病（CVD）易感性上升，研究人员不仅将注意力转向改善治疗平台，还转向改进当前的CVD预测和预后工具，以改善疾病结局。由于CVD的特征是一种炎症模式，在一定程度上涉及先天性和适应性免疫系统，中性粒细胞与淋巴细胞比值（NLR）已成为一种潜在的低成本、快速可用且可靠的炎症标志物，最近大量证据表明其在临床实践中的潜在效用。因此，在这篇文献综述中，我们将对NLR在最常见的CVD中的预后作用进行最新讨论，这些疾病包括急性和慢性冠状动脉疾病、动脉粥样硬化疾病、心力衰竭、心脏瓣膜病以及易患心房颤动的心律失常。
