Kolloch R, Offers E
Medizinische Klinik, Krankenanstalten Gilead, Bielefeld.
MMW Fortschr Med. 2003 Nov 20;145(47):42-4, 47.
There is growing evidence that aldosterone plays an important role in the development of endorgan-damage e.g. vascular and cardiac fibrosis, remodeling and endothelial dysfunction. Aldosterone-antagonism has become a novel therapeutic principle beyond its sodium retention properties in the treatment of cardiovascular diseases. In patients with severe left ventricular dysfunction spironolactone could reduce death and hospitalisation. A new selective aldosterone antagonist, eplerenone, was effective in patients with left ventricular dysfunction after myocardial infarction added to optimal medical therapy.
越来越多的证据表明，醛固酮在终末器官损伤的发展过程中起重要作用，例如血管和心脏纤维化、重塑以及内皮功能障碍。醛固酮拮抗作用已成为治疗心血管疾病的一种新的治疗原则，超越了其保钠特性。在严重左心室功能不全的患者中，螺内酯可降低死亡率和住院率。一种新型选择性醛固酮拮抗剂依普利酮，在心肌梗死后左心室功能不全的患者中，添加到最佳药物治疗方案中时有效。
