Felix-Schollaart B, Hoeksma J B, Van de Velde J P, Puyenbroek J I, Prahl-Andersen B
Department of Orthodontics, Academic Center Dentistry Amsterdam, The Netherlands.
Cleft Palate Craniofac J. 1992 Sep;29(5):470-4. doi: 10.1597/1545-1569_1992_029_0470_rhomoc_2.3.co_2.
The reproductive history was studied to evaluate if the three types of solitary, nonsyndromic clefts: cleft lip (CL), cleft lip and palate (CLP), and cleft palate (CP) are homogeneous entities. Occurrence of fetal loss, maternal health, and drug consumption of the mother during the pregnancy were compared in cases involving three types of clefts. Data was gathered from 87 children with clefts, 55 males and 32 females. Spontaneous abortions and vaginal bleeding were found to occur significantly more often in the (older) mother of a CLP child. This suggests that the factors involved in the etiology of CLP differ from the factors involved in CL and CP. Therefore, grouping of data of the three types of clefts in studies on the etiology should be avoided.
研究生殖史以评估三种类型的孤立性、非综合征性腭裂：唇裂（CL）、唇腭裂（CLP）和腭裂（CP）是否为同质实体。在涉及三种腭裂类型的病例中，比较了胎儿丢失情况、母亲健康状况以及母亲孕期的药物使用情况。数据收集自87例腭裂患儿，其中55例为男性，32例为女性。发现唇腭裂患儿的（年龄较大的）母亲发生自然流产和阴道出血的情况明显更频繁。这表明唇腭裂病因所涉及的因素与唇裂和腭裂所涉及的因素不同。因此，在病因学研究中应避免将三种腭裂类型的数据进行分组。
