Rucklidge M W M, Yentis S M, Paech M J
Magill Department of Anaesthesia, Intensive Care & Pain Management, Chelsea and Westminster Hospital, London SW10 9NH, UK.
Anaesthesia. 2004 Feb;59(2):138-41. doi: 10.1111/j.1365-2044.2004.03573.x.
We conducted a prospective, randomised, double-blind trial to study the effect of Synacthen Depot in 18 parturients with postdural puncture headache following deliberate or accidental dural puncture. Women were randomly allocated to receive either Synacthen Depot 1 mg (1 ml) or 0.9% saline 1 ml intramuscularly. Using a 10-cm visual analogue scale, severity of headache was measured before and at intervals until 48 h after injection. There was no difference in the severity of headache or requirement for epidural blood patch. We conclude that there is no advantage to the use of Synacthen Depot 1 mg for the treatment of postdural puncture headache.
我们进行了一项前瞻性、随机、双盲试验，以研究长效合成促肾上腺皮质激素对18例因故意或意外硬膜穿刺后出现硬膜穿刺后头痛的产妇的影响。将这些女性随机分配，分别肌肉注射1毫克（1毫升）长效合成促肾上腺皮质激素或1毫升0.9%生理盐水。使用10厘米视觉模拟量表，在注射前及注射后直至48小时期间每隔一段时间测量头痛的严重程度。头痛的严重程度或硬膜外血贴的需求并无差异。我们得出结论，使用1毫克长效合成促肾上腺皮质激素治疗硬膜穿刺后头痛并无优势。
