Baciu I
Cluj-Napoca Branch of the Academy of Medical Sciences.
Rev Roum Physiol (1990). 1992 Jan-Jun;29(1-2):5-11.
This review presents the results of experimental researches performed in the last decades by Cluj-Napoca physiologists, concerning the role of hypothalamic nervous centers in the triggering of the nonspecific (phagocytic reaction) and specific (primary and secondary) immune response. The following methods aiming to explore the involvement of the hypothalamic vegetative nervous centers have been applied: section of the spinal cord, somatoencephalic humoral isolation with preservation of spinal cord, stimulation or lesions under stereotaxic control of some hypothalamic areas, conditioned reflexes, electroconvulsant shocks. The results show that nervous centers from the tuberal area and from the posterior hypothalamus are involved in the regulation and integration of the immune response considered as a homeostatic function, in connexion with a preoptic, anterior and lateral hypothalamic area, with a receptive function to antigens and their endogenous products. The activation of phagocytosis (phagocytic response) can be elicited in dogs by electrical stimulation of the tuberal area and inhibited by section of the spinal cord, or by barbiturates. The specific immune response is moderately neuromodulated for antigens, as heterospecific red cells and more intensely for Salmonella and especially for the influenza virus. These results could allow an integration of other analytical data of cellular and molecular biology of immunity wider functional concept.
本综述介绍了克卢日-纳波卡的生理学家在过去几十年中进行的实验研究结果，这些研究涉及下丘脑神经中枢在引发非特异性（吞噬反应）和特异性（初次和二次）免疫反应中的作用。为探究下丘脑植物性神经中枢的参与情况，采用了以下方法：脊髓切断术、保留脊髓的躯体脑体液隔离、在立体定向控制下对下丘脑某些区域进行刺激或损伤、条件反射、电惊厥休克。结果表明，结节区和下丘脑后部的神经中枢参与了被视为一种稳态功能的免疫反应的调节和整合，这与视前区、下丘脑前部和外侧区有关，这些区域对抗原及其内源性产物具有感受功能。通过电刺激结节区可在犬类中引发吞噬作用（吞噬反应）的激活，而通过脊髓切断术或巴比妥类药物可抑制这种激活。特异性免疫反应对抗原（如异种特异性红细胞）受到适度的神经调节，而对沙门氏菌尤其是流感病毒的调节更为强烈。这些结果有助于将免疫细胞和分子生物学的其他分析数据整合到更广泛的功能概念中。
