Baciu I, Ivanof A
Physiologie. 1984 Oct-Dec;21(4):251-9.
Four groups of rats were bilaterally lesioned in the anterior, lateral, tuberal and mammillary areas of hypothalamus. Seven days later these rats, as well as controls, were immunized concomitantly with three antigens: Salmonella enteritidis, sheep red blood cells and Myxovirus influenzae A (H3N2). The primary and the secondary response were tested. The bacterial and erythrocytic antigens, with marked immunogenetic capacity, produced immune responses, which were not significantly influenced by hypothalamic lesions. The immune primary and secondary response to influenza A virus is wholly suppressed in animals with lesions in tuberal and mammillary areas of the hypothalamus. It is reduced in animals with lesions in lateral and anterior regions, as compared with controls. The secondary response is greater and more rapid in controls. It is reduced in animals with lesions in anterior and lateral hypothalamus and suppressed in those with lesions at tuberal and mammillary level. It therefore seems that the modulatory intervention of the hypothalamus in the immune process depends on the antigen, on the antigen, on the intensity of its direct effects on the immuno-competent and accessory cells and on the condition of the hypothalamic centers.
将四组大鼠的下丘脑前区、外侧区、结节区和乳头体区进行双侧损伤。七天后，这些大鼠以及对照组大鼠同时用三种抗原进行免疫：肠炎沙门氏菌、绵羊红细胞和甲型流感病毒（H3N2）。检测了初次和二次免疫反应。具有显著免疫原性的细菌和红细胞抗原产生了免疫反应，而下丘脑损伤对其没有显著影响。下丘脑结节区和乳头体区损伤的动物对甲型流感病毒的初次和二次免疫反应完全受到抑制。与对照组相比，下丘脑外侧区和前区损伤的动物免疫反应有所降低。对照组的二次免疫反应更强且更快。下丘脑前区和外侧区损伤的动物二次免疫反应降低，而下丘脑结节区和乳头体区损伤的动物二次免疫反应受到抑制。因此，下丘脑在免疫过程中的调节干预似乎取决于抗原，取决于其对免疫活性细胞和辅助细胞的直接作用强度以及下丘脑各中枢的状态。
