Woo Wai Kit, Jasim Zaid F, Handley Julian M
Department of Dermatology, Ulster Hospital, The Royal Hospitals, Grosvenor Road, Belfast BT12 6BA, N. Ireland, United Kingdom.
Dermatol Surg. 2003 Dec;29(12):1176-80; discussion 1180. doi: 10.1111/j.1524-4725.2003.29383.x.
Telangiectatic leg veins have been treated using lasers with variable success.
We aimed to examine the efficacy and tolerability of a 595-nm pulsed dye laser (PDL) and a 532-nm Nd:YAG laser using ultralong pulse duration to improve leg telangiectasias with a single treatment.
Ten subjects with leg telangiectasias up to 1.0 mm in diameter participated in the study. The telangiectatic patch was divided into two approximately equal adjacent areas. The first area was treated with a 532-nm Nd:YAG laser at a fluence of 20 J/cm2 and a pulse duration of 50 ms using a contact cooling device. The second area was treated with a 595-nm PDL at a fluence of 25 J/cm2 and a pulse duration of 40 ms using cryogen spray precooling. Each area was treated once only. Photographic evaluation was used for an assessment of response.
Two of 10 subjects had less than 25%, 3 had 25% to 50%, 2 had 50% to 75%, and 3 had more than 75% improvement after single treatment with a 532-nm Nd:YAG laser. Similarly, 2 of 10 subjects had less than 25%, 2 had 25% to 50%, and 6 had 50% to 75% improvement with the 595-nm PDL. Hyperpigmentation occurred in one subject treated with the 532-nm Nd:YAG laser and two subjects treated with the 595-nm PDL. No blistering, crusting, hypopigmentation, or scarring were observed.
Both lasers using ultralong pulse width improved leg telangiectasias after a single treatment with minimal adverse reactions.
使用激光治疗腿部毛细血管扩张症的效果各异。
我们旨在研究采用595纳米脉冲染料激光（PDL）和532纳米钕：钇铝石榴石激光并使用超长脉冲持续时间单次治疗改善腿部毛细血管扩张症的疗效和耐受性。
10名患有直径达1.0毫米腿部毛细血管扩张症的受试者参与了该研究。将毛细血管扩张斑分为两个大致相等的相邻区域。第一个区域使用接触式冷却装置，以20 J/cm²的能量密度和50毫秒的脉冲持续时间用532纳米钕：钇铝石榴石激光进行治疗。第二个区域使用冷冻喷雾预冷却，以25 J/cm²的能量密度和40毫秒的脉冲持续时间用595纳米脉冲染料激光进行治疗。每个区域仅治疗一次。通过摄影评估来评估反应。
10名受试者中，2名在使用532纳米钕：钇铝石榴石激光单次治疗后改善程度小于25%，3名改善程度为25%至50%，2名改善程度为50%至75%，3名改善程度超过75%。同样，10名受试者中，2名在使用595纳米脉冲染料激光后改善程度小于25%，2名改善程度为25%至50%，6名改善程度为50%至75%。使用532纳米钕：钇铝石榴石激光治疗的1名受试者和使用595纳米脉冲染料激光治疗的2名受试者出现了色素沉着。未观察到水疱、结痂、色素减退或瘢痕形成。
两种使用超长脉冲宽度的激光单次治疗后均改善了腿部毛细血管扩张症，且不良反应最小。
