Eremia Sorin, Li Cindy Y
Division of Dermatology, UCLA, Los Angeles, California, USA.
Dermatol Surg. 2002 Mar;28(3):244-7. doi: 10.1046/j.1524-4725.2002.01217.x.
Through the 1990s laser treatment of leg veins has been a challenge. Newer, longer wavelength lasers with variable pulse width have shown promising results for both telangiectasia and reticular leg veins. Experience with these lasers for treatment of facial telangiectasia and periorbital reticular veins is scant.
To our knowledge this is the first prospective study to evaluate a variable pulse width, cryogen spray-equipped 1064 nm Nd:YAG laser for the treatment of facial telangiectasia and larger periorbital reticular veins.
Seventeen volunteers, ages 32-67 years, skin types I-IV, with facial telangiectasia and reticular periorbital/temporal veins were treated once with the Nd:YAG laser at fluences of 125-150 J/cm2 with a 6 mm spot size and pulse widths of 25 msec for small vessels and 75-100 msec for reticular veins. Patients were examined 1 week and 1 month after the treatment. Pre- and posttreatment 35mm photographs were taken. Improvement was judged by two experienced physicians, both visually on patients and by comparison of pre- and posttreatment photographs. Results were graded as percent resolution, in five groups: 0%, 0-25%, 25-50%, 50-75%, and 75-100%.
All 17 patients completed the study. Thirty-two sites were treated (24 cheek, nose, and chin telangiectases, and 8 periorbital reticular veins). Greater than 75% improvement was observed in 97% of the treated sites. Greater than 50% improvement was observed in 100% of the treated sites. Notably, 100% of the facial reticular veins treated have essentially 100% resolution. Pain during treatment was variably perceived by patients, but occasionally sufficient for patients to express reservations about additional future treatment. Transient erythema and edema were common, but fine crusting was rare. Small areas of purpura were also quite rare.
The cryogen spray-equipped 1064 nm Nd:YAG laser was remarkably effective and safe for skin type I-IV patients. It is an excellent tool for treatment of facial telangiectasia with minimal risk of purpura. For the first time we appear to have a simple, safe, and effective treatment for 1-2 mm periorbital reticular veins. The use of topical anesthesia may be needed for some patients.
在整个20世纪90年代,腿部静脉的激光治疗一直是一项挑战。更新的、具有可变脉宽的更长波长激光在治疗毛细血管扩张和腿部网状静脉方面已显示出有前景的结果。关于这些激光治疗面部毛细血管扩张和眶周网状静脉的经验很少。
据我们所知,这是第一项前瞻性研究,旨在评估配备冷冻喷雾的可变脉宽1064nm钕:钇铝石榴石激光治疗面部毛细血管扩张和较大的眶周网状静脉。
17名年龄在32 - 67岁、皮肤类型为I - IV型、患有面部毛细血管扩张和眶周/颞部网状静脉的志愿者接受了一次钕:钇铝石榴石激光治疗,光斑大小为6mm,能量密度为125 - 150J/cm²,小血管的脉宽为25毫秒,网状静脉的脉宽为75 - 100毫秒。在治疗后1周和1个月对患者进行检查。拍摄治疗前和治疗后的35mm照片。由两名经验丰富的医生进行评估,包括直接观察患者以及比较治疗前后的照片。结果分为分辨率百分比的五组:0%、0 - 25%、25 - 50%、50 - 75%和75 - 100%。
所有17名患者完成了研究。共治疗了32个部位(24个脸颊、鼻子和下巴的毛细血管扩张,以及8个眶周网状静脉)。97%的治疗部位改善大于75%。100%的治疗部位改善大于50%。值得注意的是,所有接受治疗的面部网状静脉基本都有100%的消退。患者在治疗期间对疼痛的感受各不相同,但偶尔会严重到让患者对未来的额外治疗表示保留意见。短暂的红斑和水肿很常见,但细小结痂很少见。小面积紫癜也非常罕见。
配备冷冻喷雾的1064nm钕:钇铝石榴石激光对I - IV型皮肤患者非常有效且安全。它是治疗面部毛细血管扩张的极佳工具,紫癜风险最小。我们首次似乎有了一种简单、安全且有效的方法来治疗1 - 2mm的眶周网状静脉。一些患者可能需要使用局部麻醉。