Lee J S, Kaibara M, Sasabe H
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Biomaterials. 1992;13(14):1025-30. doi: 10.1016/0142-9612(92)90154-g.
In vitro evaluation of antithrombogenicity or anticoagulability of styrene derivative polymer with functional silyl groups, the polymer treated with acid, polystyrene and glass as a reference was attempted using a rheological method. The results were compared with those obtained from measurements of platelet adhesion. The coagulation process of blood in polymer-coated tubes was monitored using a damped oscillation-type rheometer recently developed. The change of fluidity during coagulation of blood was dependent on the polymers. Poly((4-vinylphenyl)dimethyl-2-propoxysilane) (poly(1)) was more antithrombogenic than polystyrene and acid-treated poly(1). The evaluation of antithrombogenicity or anticoagulability for the polymers and glass by the rheological method coincided well with that obtained from other methods. Furthermore, it was confirmed that the rheological method would be useful for elucidating mechanisms of coagulation of blood as well as thrombus formation in developing artificial blood-compatible materials.
尝试使用流变学方法，以具有官能性硅烷基的苯乙烯衍生物聚合物、经酸处理的该聚合物、聚苯乙烯和玻璃作为参考，对其抗血栓形成性或抗凝血性进行体外评估。将结果与通过测量血小板黏附获得的结果进行比较。使用最近开发的阻尼振荡型流变仪监测聚合物涂层管中血液的凝固过程。血液凝固过程中的流动性变化取决于聚合物。聚（（4-乙烯基苯基）二甲基-2-丙氧基硅烷）（聚（1））比聚苯乙烯和经酸处理的聚（1）具有更强的抗血栓形成性。通过流变学方法对聚合物和玻璃的抗血栓形成性或抗凝血性的评估与通过其他方法获得的评估结果非常吻合。此外，证实流变学方法对于阐明人工血液相容性材料开发过程中血液凝固以及血栓形成的机制将是有用的。
