聚合物生物材料的化学结构和表面性质对其生物相容性的影响。
Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility.
作者信息
Wang You-Xiong, Robertson John L, Spillman William B, Claus Richard O
机构信息
Fiber & Electro-Optics Research Center, Virginia Tech, Blacksburg, Virginia 24061, USA.
出版信息
Pharm Res. 2004 Aug;21(8):1362-73. doi: 10.1023/b:pham.0000036909.41843.18.
Polymeric biomaterials have extensively been used in medicinal applications. However, factors that determine their biocompatibility are still not very clear. This article reviews various effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility, including protein adsorption, cell adhesion, cytotoxicity, blood compatibility, and tissue compatibility. Understanding these aspects of biocompatibility is important to the improvement of the biocompatibility of existing polymers and the design of new biocompatible polymers.
高分子生物材料已广泛应用于医学领域。然而，决定其生物相容性的因素仍不是很清楚。本文综述了高分子生物材料的化学结构和表面性质对其生物相容性的各种影响，包括蛋白质吸附、细胞黏附、细胞毒性、血液相容性和组织相容性。了解生物相容性的这些方面对于提高现有聚合物的生物相容性以及设计新型生物相容性聚合物很重要。
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