Siński M, Kowalczyk P, Stolarczyk A, Sawionek Ł, Przybylski J
Department of Internal Medicine and Hypertension, Medical University of Warsaw, Poland.
J Physiol Pharmacol. 2003 Dec;54(4):553-9.
Respiratory failure coincides frequently with the occurrence of gastric ulceration. In advanced respiratory insufficiency hypoxemia is often accompanied by hypercapnia, which is the stimulus for central chemoreceptors as well as for carotid body chemoreceptors. The purpose of the work was to investigate the reflex effect of stimulation of central chemoreceptors on gastric mucosal blood flow (GMBF) in the rat. Central chemoreceptors were stimulated by a gas mixture composed of 10% carbon dioxide, 50% oxide and 40% nitrogen. In artificially ventilated and spontaneously breathing animals, the stimulation of central chemoreceptors caused a significant increase in gastric mucosal vascular resistance, accompanied by a marked decline in blood flow. We hypothesize that in patients with respiratory insufficiency accompanied by hypercapnia, the reflex impairment of GMBF may contribute to gastric ulceration.
呼吸衰竭常与胃溃疡的发生同时出现。在晚期呼吸功能不全时，低氧血症常伴有高碳酸血症，这是中枢化学感受器以及颈动脉体化学感受器的刺激因素。这项工作的目的是研究刺激中枢化学感受器对大鼠胃黏膜血流（GMBF）的反射效应。通过由10%二氧化碳、50%一氧化二氮和40%氮气组成的混合气体刺激中枢化学感受器。在人工通气和自主呼吸的动物中，刺激中枢化学感受器导致胃黏膜血管阻力显著增加，同时血流量明显下降。我们推测，在伴有高碳酸血症的呼吸功能不全患者中，GMBF的反射性损害可能导致胃溃疡。
