• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Suppression of graft-versus-host disease by naturally occurring regulatory T cells.

作者信息

Zeng Defu, Lan Fengshuo, Hoffmann Petra, Strober Samuel

机构信息

Division of Rheumatology and Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

出版信息

Transplantation. 2004 Jan 15;77(1 Suppl):S9-S11. doi: 10.1097/01.TP.0000106475.38978.11.

DOI:10.1097/01.TP.0000106475.38978.11
PMID:14726761
Abstract

Studies of graft-versus-host disease after allogeneic bone marrow transplantation have shown that there are subsets of freshly isolated donor T cells that induce the disease and subsets that suppress the disease. The balance of subsets in the graft determines disease severity. The authors' work on the nature of the regulatory-suppressor T cells and their mechanisms of action is summarized in this article.

摘要

相似文献

1
Suppression of graft-versus-host disease by naturally occurring regulatory T cells.
Transplantation. 2004 Jan 15;77(1 Suppl):S9-S11. doi: 10.1097/01.TP.0000106475.38978.11.
2
Simultaneous protection against allograft rejection and graft-versus-host disease after total lymphoid irradiation: role of natural killer T cells.全身淋巴照射后对同种异体移植排斥反应和移植物抗宿主病的同时保护作用：自然杀伤T细胞的作用
Transplantation. 2008 Feb 27;85(4):607-14. doi: 10.1097/TP.0b013e31816361ce.
3
Donor antigen-presenting cells regulate T-cell expansion and antitumor activity after allogeneic bone marrow transplantation.供体抗原呈递细胞在异基因骨髓移植后调节T细胞扩增和抗肿瘤活性。
Biol Blood Marrow Transplant. 2004 Aug;10(8):540-51. doi: 10.1016/j.bbmt.2004.05.007.
4
A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease.第二次预防性的主要组织相容性复合体（MHC）不匹配的骨髓移植可预防大鼠急性髓系白血病（BNML），且不会引发致死性移植物抗宿主病。
Transplantation. 2008 Jan 15;85(1):102-11. doi: 10.1097/01.tp.0000296856.53493.1f.
5
Kinetic of regulatory CD25high and activated CD134+ (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation.异基因骨髓移植后急性和慢性移植物抗宿主病期间调节性CD25高表达和活化的CD134 +（OX40）T淋巴细胞的动力学。
Br J Haematol. 2004 Sep;126(5):697-703. doi: 10.1111/j.1365-2141.2004.05108.x.
6
Modulation of graft-versus-host disease: role of regulatory T lymphocytes.移植物抗宿主病的调节：调节性T淋巴细胞的作用。
Biol Blood Marrow Transplant. 2006 Jan;12(1 Suppl 2):13-21. doi: 10.1016/j.bbmt.2005.11.002.
7
Taming transplantation with T cells.用T细胞调控移植
Nat Med. 2003 Sep;9(9):1117-8. doi: 10.1038/nm0903-1117.
8
CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation.在异基因干细胞移植后，CD4+CD25+FOXP3+调节性T细胞在多发性骨髓瘤患者的骨髓中重建并积聚。
Haematologica. 2008 Mar;93(3):423-30. doi: 10.3324/haematol.11897. Epub 2008 Feb 20.
9
Expansion of natural killer cell receptor (CD94/NKG2A)-expressing cytolytic CD8 T cells and CD4+CD25+ regulatory T cells from the same cord blood unit.来自同一脐带血单位的表达自然杀伤细胞受体（CD94/NKG2A）的溶细胞性CD8 T细胞和CD4+CD25+调节性T细胞的扩增。
Exp Hematol. 2007 Oct;35(10):1562-6. doi: 10.1016/j.exphem.2007.06.006. Epub 2007 Aug 2.
10
Total lymphoid irradiation for graft-versus-host disease protection.用于移植物抗宿主病防护的全身淋巴组织照射。
Curr Opin Oncol. 2009 Jun;21 Suppl 1:S23-6. doi: 10.1097/01.cco.0000357471.68713.35.

引用本文的文献

1
The Latest Developments in Immunomodulation of Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions, Both Allogeneic and Autologous.同种异体和自体间充质干细胞免疫调节在宫腔粘连治疗中的最新进展。
Front Immunol. 2021 Nov 15;12:785717. doi: 10.3389/fimmu.2021.785717. eCollection 2021.
2
An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease.固有淋巴细胞在移植物抗宿主病发病机制中的重要作用。
Front Immunol. 2019 Jun 6;10:1233. doi: 10.3389/fimmu.2019.01233. eCollection 2019.
3
A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke.
深入探究干细胞疗法：探寻缺血性中风的治疗选择
Stem Cells Int. 2017;2017:3267352. doi: 10.1155/2017/3267352. Epub 2017 Oct 22.
4
Adoptive T Regulatory Cell Therapy for Tolerance Induction.过继性调节性T细胞疗法诱导免疫耐受
Curr Transplant Rep. 2015 Jun 1;2(2):191-201. doi: 10.1007/s40472-015-0058-5.
5
Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI.抗CD3预处理通过调节经全身照射预处理的受体中宿主树突状细胞和供体T细胞的迁移，将移植物抗白血病效应与移植物抗宿主病分离。
Blood. 2009 Jan 22;113(4):953-62. doi: 10.1182/blood-2008-06-165522. Epub 2008 Oct 15.
6
In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease.体内活化的CD103⁺CD4⁺调节性T细胞可改善正在发生的慢性移植物抗宿主病。
Blood. 2008 Sep 1;112(5):2129-38. doi: 10.1182/blood-2008-02-140277. Epub 2008 Jun 12.
7
Inhibition of NF-kappa B during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches.在人树突状细胞分化过程中抑制核因子-κB会产生无反应性以及针对一个而非两个人类白细胞抗原DR错配的调节性T细胞活性。
Hum Immunol. 2007 Sep;68(9):715-29. doi: 10.1016/j.humimm.2007.05.010. Epub 2007 Jul 2.
8
CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques.CTLA-4阻断可降低感染SIVmac251的猕猴组织中转化生长因子-β（TGF-β）、吲哚胺2,3-双加氧酶（IDO）和病毒RNA的表达。
Blood. 2006 Dec 1;108(12):3834-42. doi: 10.1182/blood-2006-04-010637. Epub 2006 Aug 8.