Donner Ludvik R
Department of Pathology, Scott & White Memorial Hospital, The Texas A&M University System Health Science Center, College of Medicine, Temple, TX 76508, USA.
Am J Dermatopathol. 2004 Feb;26(1):63-6. doi: 10.1097/00000372-200402000-00009.
A unique, previously unreported case of transformation of cutaneous plasmacytoma into CD30+ large B-cell lymphoma is described. Both neoplastic components were immunophenotypically distinct. The plasma cells were CD20-, CD30-, CD43+, CD45+, lambda +; the blasts were CD20+, CD30+, CD43-, and CD45-. The large B-cell lymphoma has gradually become a predominant component of the neoplastic nodules. While plasma cells and blasts were both positive for Epstein-Barr virus-encoded nuclear RNAs (EBER-1), the EBV-latent membrane antigen 1 (EBV-LMP1) was expressed only in the minority of the blasts and not in the plasma cells. The neoplastic process has remained confined to the skin for more than six years since its development.
本文描述了一例独特的、此前未报道过的皮肤浆细胞瘤转化为CD30 + 大B细胞淋巴瘤的病例。两种肿瘤成分在免疫表型上截然不同。浆细胞CD20阴性、CD30阴性、CD43阳性、CD45阳性、λ阳性；母细胞CD20阳性、CD30阳性、CD43阴性、CD45阴性。大B细胞淋巴瘤已逐渐成为肿瘤结节的主要成分。虽然浆细胞和母细胞的爱泼斯坦-巴尔病毒编码核RNA（EBER - 1）均呈阳性，但EB病毒潜伏膜抗原1（EBV - LMP1）仅在少数母细胞中表达，而在浆细胞中不表达。自发病以来，肿瘤过程局限于皮肤已超过六年。
