一例与医源性或内源性免疫失调无关的原发性爱泼斯坦-巴尔病毒相关皮肤弥漫性大B细胞淋巴瘤。

A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation.

作者信息

Tokuda Yasutaka, Fukushima Mana, Nakazawa Koh, Oguchi Shinji, Koganehira Yoko, Yamaura Maki, Iijima Miwako, Murata Hiroshi, Uhara Hisashi, Takata Minoru, Saida Toshiaki, Katsuyama Tsutomu, Nakamura Sigeo

机构信息

Department of Dermatology, Matsumoto National Hospital, Matsumoto, Japan.

出版信息

J Cutan Pathol. 2008 Jul;35(7):666-71. doi: 10.1111/j.1600-0560.2007.00859.x. Epub 2008 Jan 14.

DOI:10.1111/j.1600-0560.2007.00859.x

PMID:18201237

Abstract

Cutaneous Epstein-Barr virus (EBV)-associated B-cell lymphoma (EBVBL) in non-immunocompromised patients is very rare. Here, we report a case of cutaneous EBVBL in a 72-year-old Japanese woman without any signs of immunosuppression. She showed repeated high fever and skin eruptions on the face, limbs and palms. Histological diagnosis was diffuse large B-cell lymphoma. EBV infection was detected by in situ hybridization and Southern blotting. Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern.

摘要

非免疫功能低下患者的皮肤爱泼斯坦-巴尔病毒（EBV）相关B细胞淋巴瘤（EBVBL）非常罕见。在此，我们报告一例72岁日本女性的皮肤EBVBL病例，该患者无任何免疫抑制迹象。她反复出现高热，面部、四肢和手掌出现皮疹。组织学诊断为弥漫性大B细胞淋巴瘤。通过原位杂交和Southern印迹法检测到EBV感染。病毒蛋白免疫染色显示患者潜伏膜蛋白1（LMP-1）呈阳性，爱泼斯坦-巴尔病毒核抗原-1（EBNA-2）呈阴性，表明为II型潜伏性EBV感染模式。