Borgia Francesco, Cannavò Serafinella P, Guarneri Fabrizio, Manfrè Carolina, Vaccaro Mario
Institute of Dermatology, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
J Am Acad Dermatol. 2004 Feb;50(2 Suppl):S31-3. doi: 10.1016/s0190-9622(03)01578-0.
Physical trauma has been reported as an etiologic factor of granuloma annulare, resembling a Koebner phenomenon. Moreover, granuloma annulare frequently arises at the same location of a previously healed, unrelated skin disease, mainly herpetic infection. These data seem to suggest that granuloma annulare might be a peculiar pattern of skin reaction to different stimuli, either physical or biologic, in predisposed subjects. In the case reported herein, the onset of a typical lesion of granuloma annulare at the site of saphenectomy might be explained as the result of an aberrant wound healing process, with release, by keratinocytes and/or Langerhans cells, of lymphocyte-derived chemotactic cytokines, capable of promoting the development of the granulomatous lesion.
据报道，物理创伤是环状肉芽肿的一个病因，类似于同形反应现象。此外，环状肉芽肿常出现在先前愈合的、不相关的皮肤病（主要是疱疹感染）的同一部位。这些数据似乎表明，环状肉芽肿可能是易感个体对物理或生物等不同刺激产生的一种特殊皮肤反应模式。在本文报道的病例中，隐静脉切除部位出现典型的环状肉芽肿病变，可能是异常伤口愈合过程的结果，角质形成细胞和/或朗格汉斯细胞释放淋巴细胞源性趋化细胞因子，从而促进了肉芽肿病变的发展。
