Kanekura Takuro, Kawabata Hisashi, Maruyama Ikuro, Kanzaki Tamotsu
Department of Dermatology, University Faculty of Medicine, Kogoshima, Japan.
J Am Acad Dermatol. 2004 Feb;50(2):242-6. doi: 10.1016/s0190-9622(03)02474-5.
Granulocyte and monocyte adsorption apheresis (GCAP) is a new extracorporeal apheresis treatment modality that removes pathogenic granulocytes. Recently, we found that GCAP is useful for treating pyoderma gangrenosum and pustular psoriasis. We thought that this treatment may also be effective for treating other disorders attributable to activated granulocytes and studied the efficacy of GCAP in 4 patients with psoriatic arthritis. Treatment with GCAP resulted in remarkable clearing of joint pain, suggesting that GCAP is valuable for treating arthritis as well as skin disorders. We present a detailed description of these patients and this novel therapy.
粒细胞和单核细胞吸附性血液成分单采术（GCAP）是一种新型的体外血液成分单采治疗方式，可清除致病性粒细胞。最近，我们发现GCAP对治疗坏疽性脓皮病和脓疱型银屑病有用。我们认为这种治疗可能对治疗其他由活化粒细胞引起的疾病也有效，并研究了GCAP对4例银屑病关节炎患者的疗效。GCAP治疗使关节疼痛明显减轻，这表明GCAP对治疗关节炎以及皮肤病同样有价值。我们详细描述了这些患者及这种新型疗法。
