Green A Richard, Sanchez Veronica, O'Shea Esther, Saadat Kathryn S, Elliott J Martin, Colado M Isabel
Neuropharmacology Research Group, School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Psychopharmacology (Berl). 2004 May;173(3-4):264-9. doi: 10.1007/s00213-003-1725-2. Epub 2004 Jan 15.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) administration to rats produces acute hyperthermia and long-term neurotoxic damage to 5-hydroxytryptamine (serotonin, 5-HT) neurones.
We wished to examine MDMA-induced hyperthermia in rats housed at normal (19 degrees C) and high (30 degrees C) room temperatures and investigate the effect of a prior neurotoxic lesion.
Rectal temperature was measured after administration of single or repeated doses of MDMA to rats housed at 19 degrees C and 30 degrees C.
MDMA (5 mg/kg i.p.) produced a sustained hyperthermic response in rats housed at 30 degrees C, but not in rats housed at 19 degrees C. A prior (5 weeks earlier) neurotoxic dose of MDMA (12.5 mg/kg i.p.) resulted in MDMA (5 mg/kg) producing a greater hyperthermic response in rats housed at 30 degrees C than in non-pre-treated animals. Repeated MDMA administration (binge dosing; 2, 4 or 6 mg/kg x3) produced dose-dependent hyperthermia in rats housed at 19 degrees C, with MDMA (2 mg/kg x3) having little effect. However, this dose produced significant hyperthermia (> or =2 degrees C above control values)in rats housed at 30 degrees C following the third dose. A prior neurotoxic dose of MDMA resulted in MDMA (2 mg/kg x3) producing marked hyperthermia (>1 degrees C) after the first dose and severe hyperthermia (> or =2 degrees C) after the third dose.
MDMA administration to rats housed at 30 degrees C produces a more severe hyperthermic response than that seen in rats housed at 19 degrees C. A prior neurotoxic dose enhances the response further in animals housed at 30 degrees C. Binge dosing produces a higher final peak response than a similar non-divided dose. This effect is more marked in animals housed at high room temperature. These data may have implications for recreational users of MDMA in hot environments, particularly those who may have damaged serotoninergic neurones because of prior heavy or frequent use of the drug.
给大鼠施用3,4-亚甲基二氧甲基苯丙胺（摇头丸，MDMA）会导致急性体温过高，并对5-羟色胺（血清素，5-HT）神经元造成长期神经毒性损伤。
我们希望研究在正常（19摄氏度）和高温（30摄氏度）室温饲养的大鼠中MDMA诱导的体温过高情况，并调查先前神经毒性损伤的影响。
给饲养在19摄氏度和30摄氏度的大鼠单次或重复施用MDMA后测量直肠温度。
MDMA（腹腔注射5毫克/千克）在饲养于30摄氏度的大鼠中产生持续的体温过高反应，但在饲养于19摄氏度的大鼠中未出现。先前（提前5周）给予神经毒性剂量的MDMA（腹腔注射12.5毫克/千克）导致MDMA（5毫克/千克）在饲养于30摄氏度的大鼠中产生比未预处理动物更大的体温过高反应。重复施用MDMA（暴饮暴食给药；2、4或6毫克/千克×3）在饲养于19摄氏度的大鼠中产生剂量依赖性体温过高，MDMA（2毫克/千克×3）几乎没有效果。然而，该剂量在第三次给药后在饲养于30摄氏度的大鼠中产生显著的体温过高（比对照值高≥2摄氏度）。先前给予神经毒性剂量的MDMA导致MDMA（2毫克/千克×3）在第一次给药后产生明显的体温过高（>1摄氏度），在第三次给药后产生严重的体温过高（≥2摄氏度）。
给饲养在30摄氏度的大鼠施用MDMA比给饲养在19摄氏度的大鼠产生更严重的体温过高反应。先前的神经毒性剂量在饲养于30摄氏度的动物中进一步增强了这种反应。暴饮暴食给药比类似的非分次剂量产生更高的最终峰值反应。这种效应在高温饲养的动物中更明显。这些数据可能对在炎热环境中使用MDMA的娱乐使用者有影响，特别是那些可能因先前大量或频繁使用该药物而损害了5-羟色胺能神经元的人。
