Sathar Mahomed A, York Denis F, Gouws Eleanor, Coutsoudis Anna, Coovadia Hoosen M
Department of Medicine, Nelson R. Mandela School of Medicine, Faculty of Health Sciences, University of Natal, Congella, Durban, South Africa.
Clin Infect Dis. 2004 Feb 1;38(3):405-9. doi: 10.1086/381092. Epub 2004 Jan 14.
GB virus type C (GBV-C) infection was studied in a convenience sample of 75 antiretroviral (ART)-naive African mothers with human immunodeficiency virus infection and their infants. GBV-C RNA was extracted from serum and amplified by reverse-transcriptase polymerase chain reaction. Twenty-seven (36%) of these 75 HIV-infected women tested positive for GBV-C RNA. To study transmission dynamics, we chose a random subsample of 20 of these women and their infants. In this cohort, there was evidence of postnatal transmission of GBV-C; however, it was not possible to demonstrate evidence of in utero or intrapartum transmission. In this pilot observational study, transmission of HIV from mother-to-infant occurs independently of the GBV-C infection status of the mother. The immunological indices measured tend to suggest an association with protection and or delayed progression of HIV disease in GBV-C-infected mothers.
对75名未接受过抗逆转录病毒治疗（ART）且感染人类免疫缺陷病毒的非洲母亲及其婴儿的便利样本进行了丙型GB病毒（GBV-C）感染研究。从血清中提取GBV-C RNA，并通过逆转录聚合酶链反应进行扩增。这75名感染HIV的女性中，有27名（36%）GBV-C RNA检测呈阳性。为研究传播动态，我们从这些女性及其婴儿中随机抽取了20个样本作为子样本。在这个队列中，有证据表明存在GBV-C的产后传播；然而，无法证明存在子宫内或分娩时传播的证据。在这项初步观察性研究中，HIV从母亲到婴儿的传播独立于母亲的GBV-C感染状态。所测量的免疫指标倾向于表明与GBV-C感染母亲中HIV疾病的保护和/或疾病进展延迟有关。
