Bhanich Supapol W, Remis R S, Raboud J, Millson M, Tappero J, Kaul R, Kulkarni P, McConnell M S, Mock P A, McNicholl J M, Vanprapar N, Asavapiriyanont S, Shaffer N, Butera S
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
J Infect Dis. 2009 Jul 15;200(2):227-35. doi: 10.1086/599793.
GB virus C (GBV-C) is an apathogenic virus that inhibits human immunodeficiency virus (HIV) replication in vitro. Mother-to-child transmission (MTCT) of GBV-C has been observed in multiple small studies. Our study examined the rate and correlates of MTCT of GBV-C in a large cohort of GBV-C-HIV-coinfected pregnant women in Thailand.
Maternal delivery plasma specimens from 245 GBV-C-HIV-infected women and specimens from their infants at 4 or 6 months of age were tested for GBV-C RNA. Associations with MTCT of GBV-C were examined using logistic regression.
One hundred one (41%) of 245 infants acquired GBV-C infection. MTCT of GBV-C was independently associated with maternal antiretroviral therapy (adjusted odds ratio [AOR], 5.21 [95% confidence interval {CI}, 2.12-12.81]), infant HIV infection (AOR, 0.05 [95% CI, 0.01-0.26]), maternal GBV-C load (8.0 log(10) copies/mL: AOR, 86.77 [95% CI, 15.27-481.70]; 7.0-7.9 log(10) copies/mL: AOR, 45.62 [95% CI, 8.41-247.51]; 5.0-6.9 log(10) copies/mL: AOR, 9.07 [95% CI, 1.85-44.33]: reference, <5 log(10) viral copies/mL), and caesarean delivery (AOR, 0.26 [95% CI, 0.12-0.59]).
Associations with maternal GBV-C load and mode of delivery suggest transmission during pregnancy and delivery. Despite mode of delivery being a common risk factor for virus transmission, GBV-C and HIV were rarely cotransmitted. The mechanisms by which maternal receipt of antiretroviral therapy might increase MTCT of GBV-C are unknown.
GB病毒C（GBV-C）是一种无致病性病毒，在体外可抑制人类免疫缺陷病毒（HIV）复制。多项小型研究已观察到GBV-C的母婴传播（MTCT）。我们的研究在泰国一大群GBV-C-HIV合并感染的孕妇中，检测GBV-C母婴传播的发生率及其相关因素。
检测了245名GBV-C-HIV感染女性的分娩时血浆标本以及她们4或6月龄婴儿的标本中的GBV-C RNA。采用逻辑回归分析GBV-C母婴传播的相关因素。
245名婴儿中有101名（41%）感染了GBV-C。GBV-C母婴传播独立相关因素包括：孕产妇抗逆转录病毒治疗（校正比值比[AOR]，5.21[95%置信区间{CI}，2.12 - 12.81]）、婴儿HIV感染（AOR，0.05[95%CI，0.01 - 0.26]）、孕产妇GBV-C载量（8.0 log₁₀拷贝/mL：AOR，86.77[95%CI，15.27 - 481.70]；7.0 - 7.9 log₁₀拷贝/mL：AOR，45.62[95%CI，8.41 - 247.51]；5.0 - 6.9 log₁₀拷贝/mL：AOR，9.07[95%CI，1.85 - 44.33]；对照，<5 log₁₀病毒拷贝/mL）以及剖宫产（AOR，0.26[95%CI，0.12 - 0.59]）。
与孕产妇GBV-C载量及分娩方式的相关性提示在妊娠和分娩期间发生传播。尽管分娩方式是病毒传播的常见危险因素，但GBV-C和HIV很少同时传播。孕产妇接受抗逆转录病毒治疗可能增加GBV-C母婴传播的机制尚不清楚。
