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[犬源狂犬病病毒对绵羊的实验性感染:该病毒对绵羊致病性的研究]

[Experimental infection of sheep with a rabies virus of canine origin: study of the pathogenicity for that species].

作者信息

Soria Baltazar R, Artois M, Blancou J

机构信息

Consejo Nacional de Ciencia y Tecnología, Laboratoire d'études sur la rage et la pathologie des animaux sauvages, Malzéville, Francia.

出版信息

Rev Sci Tech. 1992 Sep;11(3):829-36.

PMID:1472729
Abstract

The effects of the inoculation of a canine strain of rabies virus in sheep were studied using ten animals which received different amounts of this virus. Two subjects, inoculated with 10(5.4) mouse intracerebral lethal doses 50% (MICLD50), died from rabies after 19 and 40 days of incubation. Clinical signs were anorexia, emaciation, nervous reactions and prostration before death. The virus was recovered from different parts of the central nervous system and salivary glands with high titres. Only three animals showed an antibody response, at very low levels.

摘要

使用十只绵羊研究了接种犬源狂犬病病毒株的效果,这些绵羊接受了不同剂量的该病毒。两只接种了10(5.4)半数小鼠脑内致死剂量50%(MICLD50)的绵羊,在潜伏期19天和40天后死于狂犬病。临床症状为食欲不振、消瘦、神经反应以及死前虚脱。在中枢神经系统和唾液腺的不同部位均检测到高滴度的病毒。只有三只动物表现出抗体反应,且水平极低。

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