Yin Shihua, Gong Shusheng
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Oct;17(10):596-7, 599.
To investigate the clinical course, auxiliary examinations, histologic feature, diagnosis, differential diagnosis and treatment of giant cell tumor of temporal bone (GCTTB).
Seven cases of GCTTB, which arose in temporal bone, were collected from 1990 to 2002 and analyzed clinicopathologically.
Seven cases with the GCTTB are reported, including 3 females, 4 males. The age of 7 patients between 9 to 53 years. Five tumors located in right side temporal bone, two in left side temporal bone. One patients was pathological I grade, two I-II grade, and four II grade. The clinical course were different according to the position of the tumors: including tinnitus 6 cases, tinnitus with hear loss 5 cases(2 cases with anakus of trouble side ear), vertigo 1 case, facial paralysis with hear loss 1 case. Radical resections were performed in five cases and subtotal resections in two (recurrence, one year after operation, II grade pathologically). Postoperative Radiotherapy was conducted in three cases.
Diagnosis of GCTTB is based on typical histologic features and imagine as well as clinical information. Complete surgical resection is believed to be the most suitable treatment for GCTTB and postoperative radiotherapy may be effective.
探讨颞骨巨细胞瘤（GCTTB）的临床病程、辅助检查、组织学特征、诊断、鉴别诊断及治疗方法。
收集1990年至2002年间发生于颞骨的7例GCTTB病例，并进行临床病理分析。
报告7例GCTTB病例，其中女性3例，男性4例。7例患者年龄在9至53岁之间。5例肿瘤位于右侧颞骨，2例位于左侧颞骨。1例患者病理分级为I级，2例为I-II级，4例为II级。根据肿瘤位置不同，临床病程各异：包括耳鸣6例，耳鸣伴听力下降5例（2例患侧耳听力丧失），眩晕1例，面瘫伴听力下降1例。5例行根治性切除术，2例行次全切除术（术后1年复发，病理分级为II级）。3例术后进行了放疗。
GCTTB的诊断基于典型的组织学特征、影像学表现及临床资料。完整的手术切除被认为是GCTTB最合适的治疗方法，术后放疗可能有效。
