Liu J, Zhong D, Liu L, Sun C, Han D, Yang W
Department of Otorhinolaryngology, PLA General Hospital, Beijing 100853, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Feb;35(1):20-2.
To investigate the clinical course, histologic feature, diagnosis, differential diagnosis and treatment of giant cell reparative granuloma (GCRG).
Three cases of GCRG, which arose in the skull, were collected from 1987 to 1999 and analyzed clinicopathologically.
Two patients had the lesion in the temporal bone and one in the orbit. One patient with GCRG had a recurrence after incomplete surgical resection. Histologically, all of three cases were characterized by fibroblastic proliferation with osteoclast-like giant cell rich areas, hemorrage, and newly formed bone or osteoid trabeculae. GCRG appeared as a typical bony lytic lesion on computed tomography (CT) and as low signal intensity on both T1 and T2 weighted images on magnetic resonance imaging (MRI).
GCRG is an uncommon nonneoplastic lesion that typically arises in mandible and maxilla and its involvement in skull is rare. Although behaves benignly, GCRG may be locally aggresive. It is usually misdiagnosed for a giant cell tumor (GCT). Diagnosis of GCRG is based on typical histologic features as well as clinical information. Complete surgical resection is believed to be the most suitable treatment for GCRG and long-term follow-up by CT scanning is essential.
探讨巨细胞修复性肉芽肿（GCRG）的临床病程、组织学特征、诊断、鉴别诊断及治疗方法。
收集1987年至1999年间发生于颅骨的3例GCRG病例，并进行临床病理分析。
2例病变位于颞骨，1例位于眼眶。1例GCRG患者在手术切除不完全后复发。组织学上，所有3例均表现为成纤维细胞增生，伴有富含破骨细胞样巨细胞的区域、出血以及新形成的骨或类骨小梁。GCRG在计算机断层扫描（CT）上表现为典型的骨质溶解病变，在磁共振成像（MRI）的T1加权像和T2加权像上均呈低信号强度。
GCRG是一种罕见的非肿瘤性病变，通常发生于下颌骨和上颌骨，累及颅骨者罕见。尽管GCRG表现为良性，但可能具有局部侵袭性。它常被误诊为巨细胞瘤（GCT）。GCRG的诊断基于典型的组织学特征以及临床信息。完整的手术切除被认为是治疗GCRG最合适的方法，通过CT扫描进行长期随访至关重要。
