Gallacchi G, Frentzel A, Heidecker J L
Schmerzklinik Kirschgarten, Basel.
Praxis (Bern 1994). 2003 Dec 17;92(51-52):2201-7. doi: 10.1024/0369-8394.92.51.2201.
Studies have shown that topical NSAIDs, e.g. diclofenac, easily penetrate the skin barrier to exert local therapeutic activity. In contrast to oral administration, plasma levels after application of topical formulations are by several magnitudes lower thus explaining the lack of systemic side effects. We discuss the clinical relevance of patches containing an NSAID by demonstrating the efficacy and safety of a newly developed diclofenac patch in the topical treatment of blunt impact soft tissue injuries in a randomised, placebo controlled, double blind, multicentre study. The results showed that the diclofenac patch was significantly more effective than placebo (p < 0.0001) with a significantly faster pain relief. The diclofenac patch was well tolerated. It might be used in indications with similar pathomechanisms.
研究表明，局部用非甾体抗炎药，如双氯芬酸，可轻易穿透皮肤屏障发挥局部治疗作用。与口服给药相比，局部用制剂给药后的血浆水平要低几个数量级，这就解释了为何缺乏全身副作用。我们通过一项随机、安慰剂对照、双盲、多中心研究，展示一种新开发的双氯芬酸贴剂在钝性撞击软组织损伤局部治疗中的疗效和安全性，来讨论含非甾体抗炎药贴剂的临床相关性。结果显示，双氯芬酸贴剂比安慰剂显著更有效（p < 0.0001），疼痛缓解明显更快。双氯芬酸贴剂耐受性良好。它可用于具有类似发病机制的适应症。
