将药代动力学知识整合到药物本体中：作为支持药物基因组学的扩展。
Integrating pharmacokinetics knowledge into a drug ontology: as an extension to support pharmacogenomics.
作者信息
Chute C G, Carter J S, Tuttle M S, Haber M, Brown S H
机构信息
Division of Medical Informatics Research, Mayo Clinic, Rochester, MN, USA.
出版信息
AMIA Annu Symp Proc. 2003;2003:170-4.
Abstract
The newly developed U.S. Common Medication Information Infrastructure was used as a basis to capture and formally express the properties of drugs relevant to research and the clinical application of pharmacogenomics. Two associated taxonomies within the model, Mechanism of Action and Physiologic Effect, were enriched to accommodate pharmacogenomic use-cases; the 4,000 active ingredients in the VA NDF-RT drug file were related to the enhanced taxonomies. Pharmacokinetics were independently modeled for pharmacogenomics and tested against thirty-one high-profile drugs to demonstrate our approach.
摘要
新开发的美国通用药物信息基础设施被用作基础，以捕捉并正式表达与药物基因组学研究及临床应用相关的药物特性。该模型中的两个相关分类法，即作用机制和生理效应，得到了扩充以适应药物基因组学用例；退伍军人事务部国家药品文件（VA NDF-RT）中的4000种活性成分与扩充后的分类法相关联。针对药物基因组学独立建立了药代动力学模型，并针对31种知名药物进行了测试，以证明我们的方法。
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