Winnenburg Rainer, Bodenreider Olivier
National Library of Medicine, Maryland, MD, USA.
Stud Health Technol Inform. 2013;192:827-31.
To investigate the extent to which pharmacoepidemiologic groupings are homogeneous in terms of clinical properties.
In our analysis, we classified drug subgroups from the pharmacoepidemiologic Anatomical Therapeutic Chemical (ATC) classification system based on clinical drug properties. We established mappings from ATC fifth level drug entities to drug property annotations in the National Drug File Reference Terminology (NDF-RT), including therapeutic categories, mechanisms of action, and physiologic effects. Based on the annotations for the individual drugs we computed homogeneity scores for all ATC groups and analyzed their distribution.
We found ATC groups to be generally homogeneous, more so for mechanisms of action, and physiologic effects than for therapeutic intent. However, only half of all ATC drugs can be analyzed with this approach, in part because of missing properties in NDF-RT.
研究药物流行病学分组在临床特性方面的同质程度。
在我们的分析中，我们根据临床药物特性对药物流行病学解剖治疗化学（ATC）分类系统中的药物亚组进行了分类。我们建立了从ATC第五级药物实体到国家药品文件参考术语（NDF-RT）中药物特性注释的映射，包括治疗类别、作用机制和生理效应。基于单个药物的注释，我们计算了所有ATC组的同质得分并分析了它们的分布。
我们发现ATC组总体上是同质的，作用机制和生理效应方面比治疗意图方面更同质。然而，所有ATC药物中只有一半可以用这种方法进行分析，部分原因是NDF-RT中存在缺失的特性。
