使用生物介质生物数据整合系统和生物导体分析平台进行表达阵列注释。
Expression array annotation using the BioMediator biological data integration system and the BioConductor analytic platform.
作者信息
Mei H, Tarczy-Hornoch P, Mork P, Rossini A J, Shaker R, Donelson L
机构信息
Biomedical & Health Informatics, University of Washington, Seattle, WA, USA.
出版信息
AMIA Annu Symp Proc. 2003;2003:445-9.
This paper presents the implementation of a model for expression array annotation (EAA) using the BioMediator biological data integration system along with BioConductor, an analytic tools platform. The model presented addresses the need for annotation sources identified during BioConductor inverted exclamation mark s development. Annotation provides us with well-curated genomic background knowledge for expression array analysis and interpretation. Annotation requests are constructed and posted to the query interface of the EAA package (the EAA model implemented as a component of BioConductor). The software enumerates all possible annotation paths for queries. These are then transformed to PQL queries and processed by BioMediator. Annotation entities returned from the EAA package answer the annotation request.
本文介绍了一种使用生物中介体生物数据集成系统以及分析工具平台BioConductor进行表达阵列注释（EAA）模型的实现。所提出的模型满足了在BioConductor开发过程中确定的注释源需求。注释为表达阵列分析和解释提供了精心策划的基因组背景知识。构建注释请求并将其发布到EAA包的查询接口（作为BioConductor组件实现的EAA模型）。该软件枚举查询的所有可能注释路径。然后将这些路径转换为PQL查询并由生物中介体进行处理。从EAA包返回的注释实体回答注释请求。
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