基因索引：美国国立医学图书馆基因相关信息摘要（GeneRIFs）的特征与分析
Gene indexing: characterization and analysis of NLM's GeneRIFs.
作者信息
Mitchell Joyce A, Aronson Alan R, Mork James G, Folk Lillian C, Humphrey Susanne M, Ward Janice M
机构信息
University of Missouri -- Columbia, USA.
出版信息
AMIA Annu Symp Proc. 2003;2003:460-4.
We present an initial analysis of the National Library of Medicine's (NLM) Gene Indexing initiative. Gene Indexing occurs at the time of indexing for all 4600 journals and over 500,000 articles added to PubMed/MEDLINE each year. Gene Indexing links articles about the basic biology of a gene or protein within eight model organisms to a specific record in the NLM's LocusLink database of gene products. The result is an entry called a Gene Reference Into Function (GeneRIF) within the LocusLink database. We analyzed the numbers of GeneRIFs produced in the first year of GeneRIF production. 27,645 GeneRIFs were produced, pertaining to 9126 loci over eight model organisms. 60% of these were associated with human genes and 27% with mouse genes. About 80% discuss genes with an established MeSH Heading or other MeSH term. We developed a prototype functional alerting system for researchers based on the GeneRIFs, and a strategy to find all of the literature related to genes. We conclude that the Gene Indexing initiative adds considerable value to the life sciences research community.
我们对美国国立医学图书馆（NLM）的基因索引计划进行了初步分析。基因索引在每年为添加到PubMed/MEDLINE的4600种期刊和50多万篇文章进行索引时进行。基因索引将关于八种模式生物中某个基因或蛋白质基础生物学的文章与NLM基因产物的LocusLink数据库中的特定记录相关联。结果是在LocusLink数据库中生成一个名为基因功能参考（GeneRIF）的条目。我们分析了GeneRIF生成第一年产生的GeneRIF数量。共产生了27645个GeneRIF，涉及八种模式生物中的9126个基因座。其中60%与人类基因相关，27%与小鼠基因相关。约80%讨论的基因有既定的医学主题词表（MeSH）主题词或其他MeSH术语。我们基于GeneRIF为研究人员开发了一个原型功能警报系统，以及一种查找与基因相关的所有文献的策略。我们得出结论，基因索引计划为生命科学研究界增添了相当大的价值。
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