Barbacioru Catalin, Arunachalam Anand, Cowden Daniel, Kahwash Eiad, Saltz Joel H
Department of Biomedical Informatics, College of Medicine and Public Health, The Ohio State University, USA.
AMIA Annu Symp Proc. 2003;2003:783.
Breast cancer is the most common malignancy among women, constituting a major health problem. Different MRI techniques have been investigated in the past in order to improve the detection and diagnosis of breast tumors. One such technique is the dynamic contrast-enhanced T1-weighted magnetic resonance imaging (DCE-MRI), using diffusible CM (contrast media), such as Gd-DTPA. Here we employ a two compartment CM kinetics model (blood plasma and surrounding interstitial space being the two compartments), where the exchange of contrast agent between these compartments is bidirectionally linear. In this study we use images from 29 suspected breast carcinoma patients who underwent whole breast DCE-MRI. Each of these studies has 64 coronal sections of the whole breast, taken at 6 or 7 time points (the sampling period being about 2 minutes). Subsequent histo-pathological analysis of these patients reveal: 22 intraductal carcinomas (IDC), 3 intralobular carcinomas (ILC), 2 ductal carcinomas in-situ (DCIS) and 3 benign tumors.
乳腺癌是女性中最常见的恶性肿瘤，构成了一个重大的健康问题。过去人们研究了不同的磁共振成像（MRI）技术，以提高乳腺肿瘤的检测和诊断水平。其中一种技术是动态对比增强T1加权磁共振成像（DCE-MRI），使用可扩散的造影剂（CM），如钆喷酸葡胺（Gd-DTPA）。在此，我们采用一种双室CM动力学模型（血浆和周围间质空间为两个室），其中造影剂在这些室之间的交换是双向线性的。在本研究中，我们使用了29例接受全乳腺DCE-MRI检查的疑似乳腺癌患者的图像。这些研究中的每一项都有64个全乳腺的冠状切片，在6或7个时间点采集（采样期约为2分钟）。对这些患者随后进行的组织病理学分析显示：22例导管内癌（IDC）、3例小叶内癌（ILC）、2例导管原位癌（DCIS）和3例良性肿瘤。
