Nadrljanski Mirjan, Maksimović Ružica, Plešinac-Karapandžić Vesna, Nikitović Marina, Marković-Vasiljković Biljana, Milošević Zorica
Clinic for Radiology and Radiation Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Center for Radiology and Magnetic Resonance Imaging, Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotića 8, 11000 Belgrade, Serbia.
Eur J Radiol. 2014 Aug;83(8):1363-7. doi: 10.1016/j.ejrad.2014.05.006. Epub 2014 May 16.
The aim of this study was to contribute to the standardization of the numeric positive enhancement integral (PEI) values in breast parenchyma, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) and to evaluate the significance of the difference in PEI values between IDC and parenchyma, DCIS and parenchyma and IDC and DCIS.
In the prospective trial, we analyzed the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of 60 consecutive patients with histologically confirmed unilateral DCIS (n=30) and IDC (n=30) and defined the PEI values (range; mean ± SD) for the lesions and the breast parenchyma. Tumor-to-non-tumor (T/NT) ratios were calculated for DCIS and IDC and compared. PEI color maps (PEICM) were created. The differences in PEI values between IDC and parenchyma and between DCIS and parenchyma were tested according to t-test. Analysis of variance (ANOVA) was used to test the differences between the mean PEI values of parenchyma, DCIS and IDC.
IDC showed highly statistically different PEI numeric values compared to breast parenchyma (748.7 ± 32.2 vs. 74.6 ± 17.0; p<0.0001). The same applied to the differences in the group of patients with DCIS (428.0 ± 25.0 vs. 66.0 ± 10.6; p<0.0001). The difference between IDC, DCIS and parenchyma were also considered highly statistically significant (p<0.0001) and so were the T/NT ratios for IDC and DCIS (10.1 ± 2.4 vs. 6.6 ± 1.4; p<0.0001).
PEI numeric values may contribute to differentiation between invasive and in situ breast carcinoma.
本研究旨在推动乳腺实质、导管原位癌（DCIS）及浸润性导管癌（IDC）中数值型正性增强积分（PEI）值的标准化，并评估IDC与实质、DCIS与实质以及IDC与DCIS之间PEI值差异的意义。
在这项前瞻性试验中，我们分析了60例经组织学确诊的单侧DCIS（n = 30）和IDC（n = 30）患者的动态对比增强磁共振成像（DCE - MRI），并确定了病变及乳腺实质的PEI值（范围；均值±标准差）。计算DCIS和IDC的肿瘤与非肿瘤（T/NT）比值并进行比较。创建了PEI彩色图（PEICM）。根据t检验对IDC与实质以及DCIS与实质之间的PEI值差异进行检验。采用方差分析（ANOVA）来检验实质、DCIS和IDC的平均PEI值之间的差异。
与乳腺实质相比，IDC显示出具有高度统计学差异的PEI数值（748.7±32.2 vs. 74.6±17.0；p<0.0001）。DCIS患者组的差异情况相同（428.0±25.0 vs. 66.0±10.6；p<0.0001）。IDC、DCIS和实质之间的差异也被认为具有高度统计学意义（p<0.0001），IDC和DCIS的T/NT比值同样如此（10.1±2.4 vs. 6.6±1.4；p<0.0001）。
PEI数值可能有助于浸润性和原位乳腺癌的鉴别。
