Krommydas G, Gourgoulianis K I, Andreou G, Kotrotsiou E, Raftopulos V, Paralikas Th, Molyvdas P A
Physiology Department, Medical School, University of Thessaly, Greece.
Med Hypotheses. 2004;62(1):143-5. doi: 10.1016/s0306-9877(03)00325-6.
In contrast to Geschwind, Behan and Galaburda (GBG) theory, there is strong evidence that inheritance through maternal line is responsible for the coexistence of asthma and left-handedness early in childhood. A new model that incorporates GBG's theory and maternal inheritance is proposed. This hypothesis suggests that maternal atopy is the most important factor in the evolution of asthma and that GBG's theory applies mainly in childhood. An inherited enhanced sensitivity of fetus to testosterone may be the underlying mechanism that leads to the development of bronchial asthma.
与盖什温德、贝汉和加拉布尔达（GBG）理论相反，有强有力的证据表明，通过母系遗传导致哮喘和左利手在儿童早期共存。提出了一个将GBG理论和母系遗传纳入其中的新模型。该假说表明，母亲的特应性是哮喘发生发展中最重要的因素，且GBG理论主要适用于儿童期。胎儿对睾酮的遗传性敏感性增强可能是导致支气管哮喘发展的潜在机制。
