Sardini Alessandro, Amey Joanna S, Weylandt Karsten Henrich, Nobles Muriel, Valverde Miguel Angel, Higgins Christopher F
MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Biochim Biophys Acta. 2003 Dec 30;1618(2):153-62. doi: 10.1016/j.bbamem.2003.10.008.
Maintenance of a constant volume is essential for normal cell function. Following cell swelling, as a consequence of reduction of extracellular osmolarity or increase of intracellular content of osmolytes, animal cells are able to restore their original volume by activation of potassium and chloride conductances. The loss of these ions, followed passively by water, is responsible for the homeostatic response called regulatory volume decrease (RVD). Activation of a chloride conductance upon cell swelling is a key step in RVD. Several proteins have been proposed as candidates for this chloride conductance. The status of the field is reviewed, with particular emphasis on ClC-3, a member of the ClC family which has been recently proposed as the chloride channel involved in cell volume regulation.
维持恒定体积对于正常细胞功能至关重要。细胞肿胀后，由于细胞外渗透压降低或细胞内渗透溶质含量增加，动物细胞能够通过激活钾离子和氯离子电导来恢复其原始体积。这些离子的丢失，随后水被动跟随，导致了称为调节性容积减小（RVD）的稳态反应。细胞肿胀时氯离子电导的激活是RVD的关键步骤。已经提出了几种蛋白质作为这种氯离子电导的候选者。本文综述了该领域的现状，特别强调了ClC-3，它是ClC家族的一员，最近被认为是参与细胞容积调节的氯离子通道。
