Compton Teresa
McArdle Laboratory for Cancer Research, 1400 University Avenue, Madison, WI 53706, USA.
Trends Cell Biol. 2004 Jan;14(1):5-8. doi: 10.1016/j.tcb.2003.10.009.
The ability of human cytomegalovirus (HCMV) to infect an extensive range of cell types has complicated efforts to identify cellular receptors for this significant pathogen. Recent findings demonstrate that epidermal growth factor receptor (EGFR) serves also as a receptor for HCMV. Additional evidence has shown that HCMV entry occurs in concert with immune detection through toll-like receptors. Here, the implications of EGFR activation, the existence of other receptors and the coordination of entry with the innate sensing are discussed.
人类巨细胞病毒（HCMV）能够感染多种细胞类型，这使得识别这种重要病原体的细胞受体变得复杂。最近的研究结果表明，表皮生长因子受体（EGFR）也是HCMV的一种受体。更多证据显示，HCMV的进入与通过Toll样受体的免疫检测协同发生。在此，我们将讨论EGFR激活的影响、其他受体的存在以及进入过程与先天感知的协调。
