Swissa M, Cohen Y, Shoenfeld Y
Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Leuk Lymphoma. 1992 May;7(1-2):117-22. doi: 10.3109/10428199209053610.
Sera of 84 patients with Hodgkin's disease (HD) and 55 patients with non-Hodgkin's lymphoma (NHL) were examined for the presence of autoantibodies to ssDNA, dsDNA, Poly (I), Poly (G), cardiolipin, histones, RNP. Sm, Ro (SS/A), La (SS/B) and the common anti-DNA idiotype (16/6) using an enzyme-linked immunosorbent assay (ELISA). Anti-ssDNA antibodies were detected in the sera of 20 patients with lymphoma (23.8%), more among those with NHL than HD (16 vs. 4 patients p < 0.01). Anti-RNP and anti-Sm antibodies were found in 16 (21.7%) and 14 lymphoma patients (20%) respectively, significantly more than in the controls (p < 0.05) in both antibodies). These findings remained valid following subgrouping of the patients into those with HD and NHL. With all the other autoantibodies examined no significant difference could be observed in the incidence between lymphoma patients and controls. These results differ from our previous survey carried out on sera of patients with solid tumors in whom no increased frequency of any of the autoantibodies could be determined. In view of the evidence suggesting an increased risk of lymphoma in a number of autoimmune diseases our results extend this relationship to an increased incidence of autoantibodies among patients with lymphoma.
采用酶联免疫吸附测定（ELISA）法检测了84例霍奇金病（HD）患者和55例非霍奇金淋巴瘤（NHL）患者血清中抗单链DNA（ssDNA）、双链DNA（dsDNA）、聚肌苷酸（Poly (I)）、聚鸟苷酸（Poly (G)）、心磷脂、组蛋白、核糖核蛋白（RNP）、Sm、Ro（SS/A）、La（SS/B）及常见抗DNA独特型（16/6）自身抗体的存在情况。在20例淋巴瘤患者（23.8%）血清中检测到抗ssDNA抗体，其中NHL患者多于HD患者（16例对4例，p<0.01）。分别在16例（21.7%）和14例淋巴瘤患者（20%）中发现抗RNP和抗Sm抗体，两者均显著多于对照组（p<0.05）。将患者分为HD组和NHL组后，这些结果仍然成立。在检测的所有其他自身抗体方面，淋巴瘤患者与对照组之间的发生率未观察到显著差异。这些结果与我们之前对实体瘤患者血清进行的调查不同，在实体瘤患者中未发现任何自身抗体频率增加。鉴于有证据表明在一些自身免疫性疾病中淋巴瘤风险增加，我们的结果将这种关系扩展至淋巴瘤患者自身抗体发生率增加。
