对乙酰氨基酚通过抑制葡萄球菌肠毒素A致热家兔的谷氨酸释放发挥解热作用。

Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits.

作者信息

Huang Wu-Tein, Wang Jhi-Joung, Lin Mao-Tsun

机构信息

Department of Health Care Administration, Di Wan College of Management, Madou, Tainan 721, Taiwan.

出版信息

Neurosci Lett. 2004 Jan 23;355(1-2):33-6. doi: 10.1016/j.neulet.2003.10.050.

DOI:10.1016/j.neulet.2003.10.050

PMID:14729228

Abstract

The present study was designed to determine whether the inhibition of glutamate release in organum vasculosum laminae terminalis (OVLT) of rabbit brain by acetaminophen might be protective in a whole-animal model of staphylococcal enterotoxin A (SEA) fever. Unanesthetized rabbits were administered intravenously with SEA, and both colonic temperature (Tco) and glutamate release in OVLT were measured simultaneously. The glutamate release in OVLT was measured with a microdialysis probe previously implanted. Both the Tco and glutamate release in OVLT were simultaneously increased following intravenous administration of SEA. The SEA-induced rise in both the Tco and the levels of glutamate release in OVLT were suppressed by pretreatment with intravenous injection of acetaminophen (1, 5 or 10 mg/kg). Furthermore, treatment of OVLT with acetaminophen (50-150 microg) attenuated the fever-like hyperthermia induced by intra-OVLT injection of glutamate. Our results show acetaminophen may reduce glutamate release in OVLT and result in antipyresis.

摘要

本研究旨在确定对乙酰氨基酚对兔脑海绵体终板血管器（OVLT）中谷氨酸释放的抑制作用在葡萄球菌肠毒素A（SEA）发热的全动物模型中是否具有保护作用。对未麻醉的兔子静脉注射SEA，并同时测量结肠温度（Tco）和OVLT中的谷氨酸释放。用先前植入的微透析探针测量OVLT中的谷氨酸释放。静脉注射SEA后，Tco和OVLT中的谷氨酸释放均同时增加。静脉注射对乙酰氨基酚（1、5或10 mg/kg）预处理可抑制SEA诱导的Tco升高和OVLT中谷氨酸释放水平的升高。此外，用对乙酰氨基酚（50 - 150微克）处理OVLT可减轻OVLT内注射谷氨酸诱导的发热样高热。我们的结果表明，对乙酰氨基酚可能会减少OVLT中的谷氨酸释放并导致解热作用。