Hashimoto M, Ueno T, Iriki M
Department of Physiology, Yamanashi Medical University, Japan.
Pflugers Arch. 1994 Nov;429(1):50-7. doi: 10.1007/BF02584029.
Experiments were designed to clarify the role of the brain's organum vasculosum laminae terminalis (OVLT) in the development of fever in rabbits. Rectal and ear skin temperatures were recorded in conscious animals in which the OVLT had been electrolytically destroyed or in which the preoptic anterior hypothalamus (PO/AH) had been transected bilaterally. When the OVLT had been ablated the febrile responses to intravenous injection of interleukin-1 beta (IL-1 beta) or tumour necrosis factor alpha were significantly attenuated, while those to intracerebroventricular injection of IL-1 beta were not affected. Fever induced by intracerebroventricular injection of prostaglandin E2 (PGE2) was prolonged significantly. The febrile responses to intravenous injection of IL-1 beta and to intracerebroventricular injection of PGE2 were attenuated when the transection was located caudally to the anterior wall of the third ventricle and extended laterally more than about 3 mm in the ventricular wall. The results show that the OVLT region is a site through which signals to increase body temperature are transferred from the blood to the brain in rabbits.
实验旨在阐明兔脑终板血管器（OVLT）在发热过程中的作用。记录清醒动物的直肠和耳部皮肤温度，这些动物的OVLT已被电解破坏，或双侧视前区下丘脑前部（PO/AH）已被横断。当OVLT被切除时，静脉注射白细胞介素-1β（IL-1β）或肿瘤坏死因子α引起的发热反应显著减弱，而脑室内注射IL-1β引起的发热反应不受影响。脑室内注射前列腺素E2（PGE2）诱导的发热显著延长。当横断位于第三脑室前壁尾侧且在室壁向外侧延伸超过约3mm时，静脉注射IL-1β和脑室内注射PGE2引起的发热反应减弱。结果表明，在兔中，OVLT区域是体温升高信号从血液传递至脑的一个部位。
