Mothilal K K, Karunakaran Chandran, Rajendran Ayyapan, Murugesan Ramachandran
Department of Chemistry, Saraswathi Narayanan College, Madurai 625 022, Tamil Nadu, India.
J Inorg Biochem. 2004 Feb;98(2):322-32. doi: 10.1016/j.jinorgbio.2003.10.017.
An interesting series of metal complexes of thiabendazole (tbz) is synthesized and characterized by elemental analyses and spectroscopic studies. The crystal structure of the hydrogen bonded one dimensional Co(II) complex, namely Co(tbz)(2)(NO(3))(H(2)O) is solved by single crystal X-ray diffraction. The complex crystallizes in monoclinic space group P2(1)/a with unit cell parameters, a=14.366(2), b=11.459(4), c=15.942(3) A, beta=113.78(3) degrees and z=4. The unit cell packing reveals an extensive hydrogen bonding involving a water molecule, nitrate ligands and the protonated nitrogen atoms of the tbz ligands, resulting in a one dimensional hydrogen bonding pattern. The antimicrobial activity of the complexes against selected bacteria (Escherichia coli and Bacillus subtilis) and yeast (Aspergillus flavues) is estimated. The relationship between the enzymatic production of ROS and antimicrobial activity of the complexes is examined, and a good correlation between two factors is found. Photodynamic quantum yields of singlet oxygen production (RNO bleaching assay) and rate of superoxide generation (SOD inhibitable ferricytochrome c reduction assay and EPR spin trapping experiments using 5,5-dimethyl-1-pyrroline-N-oxide as spin trap) by the metal complexes have been studied.
合成了一系列有趣的噻苯达唑（tbz）金属配合物，并通过元素分析和光谱研究对其进行了表征。通过单晶X射线衍射解析了氢键一维Co（II）配合物Co（tbz）(2)(NO(3))(H(2)O)的晶体结构。该配合物结晶于单斜空间群P2(1)/a，晶胞参数为a = 14.366(2)，b = 11.459(4)，c = 15.942(3) Å，β = 113.78(3)°，z = 4。晶胞堆积显示出广泛的氢键作用，涉及一个水分子、硝酸根配体和tbz配体的质子化氮原子，形成了一维氢键模式。评估了这些配合物对选定细菌（大肠杆菌和枯草芽孢杆菌）和酵母（黄曲霉）的抗菌活性。研究了配合物的ROS酶促产生与抗菌活性之间的关系，发现这两个因素之间存在良好的相关性。研究了金属配合物产生单线态氧的光动力量子产率（RNO漂白测定）和超氧阴离子生成速率（SOD抑制的细胞色素c还原测定以及使用5,5-二甲基-1-吡咯啉-N-氧化物作为自旋捕获剂的EPR自旋捕获实验）。
