Singh Vinod P, Gupta Parul
Chemistry Department, Banaras Hindu University, India.
J Enzyme Inhib Med Chem. 2008 Dec;23(6):797-805. doi: 10.1080/14756360701733136.
Complexes of the type [M(bssdh)]Cl and [M(dspdh)]Cl, where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II); Hbssdh = benzil salicylaldehyde succinic acid dihydrazone, Hdspdh = diacetyl salicylaldehyde phthalic acid dihydrazone have been synthesized and characterized with the help of elemental analyses, electrical conductance, magnetic susceptibility measurements, electronic, ESR and IR spectra and X-ray diffraction studies. Magnetic moment values and electronic spectral transitions indicate a spin free octahedral structure for Co(II), Ni(II) and Cu(II) complexes. IR spectral studies suggest that both the ligands behave as monobasic hexadentate ligands coordinating through three > C = O, two > C = N- and a phenolate group to the metal. ESR spectra of Cu(II) complexes are axial type and suggest d(x(2)-y(2)) as the ground state. X-ray powder diffraction parameters for [Co(bssdh)]Cl and [Co(dspdh)]Cl complexes correspond to an orthorhombic crystal lattice. The ligands as well as their metal complexes show a significant antifungal and antibacterial activity against various fungi and bacteria. The metal complexes are more active than the parent ligands.
已合成了[M(bssdh)]Cl和[M(dspdh)]Cl类型的配合物，其中M = Co(II)、Ni(II)、Cu(II)、Zn(II)和Cd(II)；Hbssdh = 联苯甲酰水杨醛琥珀酸二腙，Hdspdh = 二乙酰水杨醛邻苯二甲酸二腙，并借助元素分析、电导率、磁化率测量、电子光谱、电子自旋共振（ESR）光谱、红外光谱以及X射线衍射研究对其进行了表征。磁矩值和电子光谱跃迁表明Co(II)、Ni(II)和Cu(II)配合物具有自旋自由的八面体结构。红外光谱研究表明，两种配体均表现为通过三个>C = O、两个>C = N-和一个酚盐基团与金属配位的一元六齿配体。Cu(II)配合物的电子自旋共振光谱为轴向型，表明基态为d(x(2)-y(2))。[Co(bssdh)]Cl和[Co(dspdh)]Cl配合物的X射线粉末衍射参数对应于正交晶格。这些配体及其金属配合物对各种真菌和细菌均表现出显著的抗真菌和抗菌活性。金属配合物比母体配体更具活性。
