Ohyama Takashiro, Nishide Takuji, Iwata Hiroo, Taki Waro
Department of Neurosurgery, Mie University School of Medicine, Mie, Japan.
AJNR Am J Neuroradiol. 2004 Jan;25(1):53-9.
Gold has often been used in medicine because of its radiopacity and flexibility. To perform stent-supported coil embolization of intracranial aneurysms, we prepared a gold stent and examined its flexibility, radiopacity, and thrombogenic properties in comparison with a stainless steel device implanted in vitro and in vivo.
Gold stents were prepared by plating gold on stainless steel stents as a template. Their mechanical properties and trackability in vitro were determined and compared with those of stainless steel stents of the same design. Twenty gold stents and two stainless steel stents were implanted in canine external carotid, vertebral, and renal arteries, as a muscle branch of the maxillary arteries, to examine their performance in vivo.
The gold stent exhibited much less radial force and greater flexibility than the stainless steel stent. It also demonstrated superior trackability and radiopacity in the experimental endovascular procedures in canines. Histologic examination showed good patency of the stented artery with slight endothelial hypertrophy.
Although there is still room for more radial strength, less influence on intimal hypertrophy, a more suitable flexibility, and a smoother surface, the superior trackability and radiopacity of gold stents seem to support use of this device for the endovascular treatment of intracranial aneurysms.
由于金具有显影性和柔韧性，其在医学领域常被使用。为了进行颅内动脉瘤的支架辅助弹簧圈栓塞术，我们制备了一种金支架，并与植入体外和体内的不锈钢装置相比，检测了其柔韧性、显影性和血栓形成特性。
以不锈钢支架为模板，通过镀金制备金支架。测定其体外机械性能和可追踪性，并与相同设计的不锈钢支架进行比较。将20个金支架和2个不锈钢支架植入犬的颈外动脉、椎动脉和肾动脉（作为上颌动脉的肌支），以检测其体内性能。
金支架比不锈钢支架表现出更小的径向力和更大的柔韧性。在犬类实验性血管内操作中，它还表现出更好的可追踪性和显影性。组织学检查显示，置入支架的动脉通畅良好，伴有轻微的内皮肥厚。
尽管在径向强度、对内膜肥厚的影响、更合适的柔韧性和更光滑的表面方面仍有改进空间，但金支架优越的可追踪性和显影性似乎支持将该装置用于颅内动脉瘤的血管内治疗。
