神经肽Y及对神经肽Y受体亚型具有选择性的激动剂对豚鼠小肠和大鼠脑微动脉的影响。
Effects of neuropeptide Y and agonists selective for neuropeptide Y receptor sub-types on arterioles of the guinea-pig small intestine and the rat brain.
作者信息
Xia J, Neild T O, Kotecha N
机构信息
Department of Physiology, Monash University, Clayton, Victoria, Australia.
出版信息
Br J Pharmacol. 1992 Nov;107(3):771-6. doi: 10.1111/j.1476-5381.1992.tb14522.x.
Abstract
- The actions of neuropeptide Y (NPY) and agonists selective for NPY receptor subtypes were examined on arterioles from the guinea-pig small intestine and the rat pia in order to characterize the receptors mediating the vasoconstrictor and potentiating effects of NPY. 2. A method was developed for measuring the potentiating effects of NPY in situations where it was not possible to obtain a full concentration-response relationship for the vasoconstrictor. NPY, 50 nM, had a greater potentiating effect on the guinea-pig intestinal arterioles than those from the rat pia. 3. NPY and the Y1-selective agonist, NPY[Leu31,Pro34], potentiated the constrictor responses to U46619 in both arterioles and responses to noradrenaline in the guinea-pig arterioles. There was marked desensitization of the potentiating effect, and cross-desensitization between NPY and NPY[Leu31,Pro34]. Both NPY and NPY[Leu31,Pro34] caused constriction of the rat pial arterioles but not of those from the guinea-pig intestine. 4. The Y2-selective agonist PYY(13-36) caused no potentiation or vasoconstriction and did not affect the potentiation by NPY or NPY[Leu31,Pro34]. 5. The potentiating and vasoconstrictor effects of NPY on these arterioles were mediated by Y1 receptors.
摘要
- 研究了神经肽Y（NPY）及其对NPY受体亚型具有选择性的激动剂对豚鼠小肠和大鼠软脑膜小动脉的作用，以鉴定介导NPY血管收缩和增强作用的受体。2. 开发了一种方法，用于在无法获得血管收缩剂完整浓度 - 反应关系的情况下测量NPY的增强作用。50 nM的NPY对豚鼠肠小动脉的增强作用大于对大鼠软脑膜小动脉的增强作用。3. NPY和Y1选择性激动剂NPY[Leu31,Pro34]增强了两种小动脉对U46619的收缩反应以及豚鼠小动脉对去甲肾上腺素的反应。增强作用存在明显的脱敏现象，且NPY与NPY[Leu31,Pro34]之间存在交叉脱敏。NPY和NPY[Leu31,Pro34]均可使大鼠软脑膜小动脉收缩，但对豚鼠肠小动脉无此作用。4. Y2选择性激动剂PYY(13 - 36) 既不产生增强作用也不引起血管收缩，且不影响NPY或NPY[Leu31,Pro34]的增强作用。5. NPY对这些小动脉的增强和血管收缩作用由Y1受体介导。
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