豚鼠小肠小动脉中由神经肽Y Y2受体介导的血管收缩作用的减弱。
Reduction of vasoconstriction mediated by neuropeptide Y Y2 receptors in arterioles of the guinea-pig small intestine.
作者信息
Neild T O, Lewis C J
机构信息
Department of Human Physiology, Flinders University, Adelaide, Australia.
出版信息
Br J Pharmacol. 1995 May;115(2):220-1. doi: 10.1111/j.1476-5381.1995.tb15865.x.
Abstract
Brief applications of a high-K+ solution were used to evoke transient constrictions of arterioles from the guinea-pig small intestine. Analogues of neuropeptide Y (NPY) selective for Y2-receptors reduced the constrictions, whereas NPY or a Y1-selective analogue potentiated the constrictions. We conclude that arteriolar smooth muscle has both Y1 and Y2 receptors, and suggest that Y2 receptors inhibit vasoconstriction by modulating the opening of voltage-sensitive Ca2+ channels. This may be related to the role of NPY that is present in some vasodilator nerves.
摘要
使用高钾溶液的短暂应用来诱发豚鼠小肠小动脉的短暂收缩。对Y2受体具有选择性的神经肽Y（NPY）类似物可减轻收缩，而NPY或Y1选择性类似物则增强收缩。我们得出结论，小动脉平滑肌同时具有Y1和Y2受体，并表明Y2受体通过调节电压敏感性Ca2+通道的开放来抑制血管收缩。这可能与某些血管舒张神经中存在的NPY的作用有关。
相似文献
1
Reduction of vasoconstriction mediated by neuropeptide Y Y2 receptors in arterioles of the guinea-pig small intestine.豚鼠小肠小动脉中由神经肽Y Y2受体介导的血管收缩作用的减弱。
Br J Pharmacol. 1995 May;115(2):220-1. doi: 10.1111/j.1476-5381.1995.tb15865.x.
2
Inhibition of vasoconstriction and Ca2+ currents mediated by neuropeptide Y Y2 receptors.
J Smooth Muscle Res. 1999 Oct-Dec;35(5-6):147-56. doi: 10.1540/jsmr.35.147.
3
Effects of neuropeptide Y and agonists selective for neuropeptide Y receptor sub-types on arterioles of the guinea-pig small intestine and the rat brain.神经肽Y及对神经肽Y受体亚型具有选择性的激动剂对豚鼠小肠和大鼠脑微动脉的影响。
Br J Pharmacol. 1992 Nov;107(3):771-6. doi: 10.1111/j.1476-5381.1992.tb14522.x.
4
A role for neuropeptide Y in rat iridial arterioles.神经肽Y在大鼠虹膜小动脉中的作用。
Am J Physiol. 1997 Nov;273(5):H2119-27. doi: 10.1152/ajpheart.1997.273.5.H2119.
5
Characterization of the receptor response for the neuropeptide Y-evoked suppression of parasympathetically-mediated contractions in the guinea pig trachea.神经肽Y诱发豚鼠气管副交感神经介导收缩抑制的受体反应特性
Regul Pept. 1997 Aug 15;71(2):97-101. doi: 10.1016/s0167-0115(97)01023-9.
6
Activation of neuropeptide Y1 and neuropeptide Y2 receptors by substituted and truncated neuropeptide Y analogs: identification of signal epitopes.取代和截短的神经肽Y类似物对神经肽Y1和神经肽Y2受体的激活：信号表位的鉴定
Eur J Pharmacol. 1993 Mar 2;232(2-3):271-8. doi: 10.1016/0014-2999(93)90784-f.
7
Modulation of submucosal arteriolar tone by neuropeptide Y Y2 receptors in the guinea-pig small intestine.神经肽Y Y2受体对豚鼠小肠黏膜下小动脉张力的调节作用
J Auton Nerv Syst. 1998 Jun 10;70(3):157-63. doi: 10.1016/s0165-1838(98)00049-6.
8
Distribution and functional effects of neuropeptide Y on equine ureteral smooth muscle and resistance arteries.神经肽Y对马输尿管平滑肌和阻力动脉的分布及功能影响
Regul Pept. 1997 Apr 30;69(3):155-65. doi: 10.1016/s0167-0115(97)00003-7.
9
Mechanism of the potentiation of vasoconstriction by neuropeptide Y in arterioles from the submucosa of the guinea-pig small intestine.
Clin Exp Pharmacol Physiol. 1997 Mar-Apr;24(3-4):217-22. doi: 10.1111/j.1440-1681.1997.tb01810.x.
10
Differential vascular effects of neuropeptide Y(NPY) selective receptor agonists.神经肽Y（NPY）选择性受体激动剂的不同血管效应。
Experientia. 1994 Oct 15;50(10):936-8. doi: 10.1007/BF01923482.
引用本文的文献
1
Conducted depolarization in arteriole networks of the guinea-pig small intestine: effect of branching of signal dissipation.豚鼠小肠小动脉网络中的传导性去极化：信号消散分支的影响。
J Physiol. 1996 Oct 1;496 ( Pt 1)(Pt 1):229-44. doi: 10.1113/jphysiol.1996.sp021680.
本文引用的文献
1
Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia.神经肽Y和胰多肽可降低成年大鼠颈上神经节急性分离神经元中的钙电流。
J Pharmacol Exp Ther. 1993 May;265(2):903-9.
2
A novel neuropeptide Y analog, N-acetyl [Leu28,Leu31]neuropeptide Y-(24-36), with functional specificity for the presynaptic (Y2) receptor.一种新型神经肽Y类似物，N-乙酰基[亮氨酸28，亮氨酸31]神经肽Y-(24-36)，对突触前（Y2）受体具有功能特异性。
Eur J Pharmacol. 1994 May 17;267(3):253-62. doi: 10.1016/0922-4106(94)90148-1.
3
Characterization of vascular postsynaptic NPY receptor function and regulation and differential sensitivity of Y1 and Y2 receptor function to changes in extracellular calcium availability and prior in vitro peptide exposure.血管突触后神经肽Y受体功能、调节的特征以及Y1和Y2受体功能对细胞外钙可用性变化和先前体外肽暴露的差异敏感性
Neuropeptides. 1993 Nov;25(5):289-98. doi: 10.1016/0143-4179(93)90046-d.
4
Presynaptic inhibition of cardiac vagal postganglionic nerves by neuropeptide Y.神经肽Y对心脏迷走神经节后神经的突触前抑制
Neurosci Lett. 1987 Dec 16;83(1-2):101-6. doi: 10.1016/0304-3940(87)90223-0.
5
6
Co-localization of neuropeptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea pig uterine artery.神经肽Y、血管活性肠肽和强啡肽在豚鼠子宫动脉非去甲肾上腺素能轴突中的共定位
Neurosci Lett. 1985 Nov 20;62(1):31-7. doi: 10.1016/0304-3940(85)90280-0.
7
A study of the phasic response of arterioles of the guinea pig small intestine to prolonged exposure to norepinephrine.一项关于豚鼠小肠小动脉对长时间暴露于去甲肾上腺素的相位反应的研究。
Microvasc Res. 1989 Sep;38(2):186-99. doi: 10.1016/0026-2862(89)90027-7.
8
Neuropeptide Y receptor subtypes, Y1 and Y2.神经肽Y受体亚型，Y1和Y2。
Ann N Y Acad Sci. 1990;611:7-26. doi: 10.1111/j.1749-6632.1990.tb48918.x.
9
Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase.神经肽Y的Y1受体与细胞内钙的动员及腺苷酸环化酶的抑制相偶联。
FEBS Lett. 1990 Jan 15;260(1):73-8. doi: 10.1016/0014-5793(90)80069-u.
10
Effects of neuropeptide Y and agonists selective for neuropeptide Y receptor sub-types on arterioles of the guinea-pig small intestine and the rat brain.神经肽Y及对神经肽Y受体亚型具有选择性的激动剂对豚鼠小肠和大鼠脑微动脉的影响。
Br J Pharmacol. 1992 Nov;107(3):771-6. doi: 10.1111/j.1476-5381.1992.tb14522.x.
Zotero 插件