局灶性肝脾念珠菌病患者循环中念珠菌甘露糖蛋白抗原缺乏。

Lack of circulating Candida mannoprotein antigen in patients with focal hepatosplenic candidiasis.

作者信息

Girmenia Corrado, Martino Pietro, De Bernardis Flavia, Boccanera Maria, Cassone Antonio

机构信息

Dipartimento di Biotecnologie Cellulari ed Ematologia, University 'La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.

出版信息

J Med Microbiol. 2004 Feb;53(Pt 2):103-106. doi: 10.1099/jmm.0.05297-0.

DOI:10.1099/jmm.0.05297-0

PMID:14729929

Abstract

The significance of Candida mannoprotein serum detection in 15 patients with haematological malignancies and proven (six cases) or probable (nine cases) hepatosplenic candidiasis was retrospectively evaluated. Circulating mannoprotein antigen was detected in three of six and in one of two serum samples from two patients with probable infection. The antigen was not detected in 38 serum samples of 13 (87%) patients. Thus, in contrast to other deep-seated Candida infections, mannoprotein is infrequently detectable during focal hepatosplenic candidiasis and does not appear to be of diagnostic value.

摘要

对15例血液系统恶性肿瘤且已确诊（6例）或可能（9例）患有肝脾念珠菌病的患者，回顾性评估了念珠菌甘露聚糖蛋白血清检测的意义。在2例可能感染患者的6份血清样本中的3份以及2份血清样本中的1份中检测到循环甘露聚糖蛋白抗原。在13例患者（87%）的38份血清样本中未检测到该抗原。因此，与其他深部念珠菌感染不同，在局灶性肝脾念珠菌病期间很少能检测到甘露聚糖蛋白，且其似乎没有诊断价值。