利什曼原虫和锥虫中参与U插入/缺失RNA编辑的线粒体蛋白质和复合体
Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing.
作者信息
Simpson Larry, Aphasizhev Ruslan, Gao Guanghan, Kang Xuedong
机构信息
Department of Microbiology, Immunology and Molecular Genetics and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.
出版信息
RNA. 2004 Feb;10(2):159-70. doi: 10.1261/rna.5170704.
Abstract
A number of mitochondrial proteins have been identified in Leishmania sp. and Trypanosoma brucei that may be involved in U-insertion/deletion RNA editing. Only a few of these have yet been characterized sufficiently to be able to assign functional names for the proteins in both species, and most have been denoted by a variety of species-specific and laboratory-specific operational names, leading to a terminology confusion both within and outside of this field. In this review, we summarize the present status of our knowledge of the orthologous and unique putative editing proteins in both species and the functional motifs identified by sequence analysis and by experimentation. An online Supplemental sequence database (http://164.67.60.200/proteins/protsmini1.asp) is also provided as a research resource.
摘要
在利什曼原虫属和布氏锥虫中已鉴定出多种可能参与U插入/缺失RNA编辑的线粒体蛋白。其中只有少数几种已得到充分表征，能够为这两个物种中的蛋白质赋予功能名称，而大多数则由各种物种特异性和实验室特异性的操作名称表示，导致该领域内外的术语混乱。在这篇综述中，我们总结了目前我们对这两个物种中直系同源和独特的假定编辑蛋白的了解情况，以及通过序列分析和实验鉴定的功能基序。还提供了一个在线补充序列数据库（http://164.67.60.200/proteins/protsmini1.asp）作为研究资源。
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