Kostowski Wojciech, Krzaścik Paweł
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02-957 Warszawa, Poland.
Pol J Pharmacol. 2003 Nov-Dec;55(6):957-63.
The influence of neonatal serotonergic lesion on adult behavior in locomotor and depression models was studied in male Wistar rats. When 3-day-old rats were injected intracisternally with 5,7-dihydroxytryptamine (5,7-DHT), a marked depletion of brain 5-HT was observed when animals were killed 3 months after the treatment. Brain catecholamine content was generally not changed by neurotoxin treatment. The behavioral consequence of intracisternal 5,7-DHT administration to developing rats consisted in reduction of adult rats' activity in the forced swimming test. Both desipramine, and, to the lesser extent, fluoxetine, reversed 5,7-DHT-induced immobility of animals.
在雄性Wistar大鼠中研究了新生期血清素能损伤对运动和抑郁模型中成年行为的影响。当给3日龄大鼠脑池内注射5,7-二羟基色胺（5,7-DHT）时，在治疗3个月后处死动物时观察到脑5-羟色胺（5-HT）明显耗竭。神经毒素治疗一般不会改变脑儿茶酚胺含量。给发育中的大鼠脑池内注射5,7-DHT的行为后果是成年大鼠在强迫游泳试验中的活动减少。地昔帕明以及程度较轻的氟西汀均可逆转5,7-DHT诱导的动物不动状态。
