Breese G R, Vogel R A, Mueller R A
J Pharmacol Exp Ther. 1978 Jun;205(3):587-95.
Intracisternal administration of 5,7-dihydroxytryptamine (5,7-DHT) to immature rats produced a marked reduction of brain norepinephrine and serotonin. Accompanying these reductions of brain amines were a decrease in body weight and alterations in behavior. After treatment with 5,7-DHT at 3 days of age, locomotor activity was significantly elevated at 14 days of age, but was reduced at 28 days of age. 5,7-DHT alone also induced a significant deficit in acquisition of the shuttle-box avoidance response and blocked body movements observed after decapitation. Treatment with either pargyline or desipramine before injection of 5,7-DHT eliminated the effect of 5,7-DHT on noradrenergic fibers while enhancing the effects of 5,7-DHT on brain serotonergic fibers. These treatments also minimized the deficits of 5,7-DHT on growth and on acquisition of the avoidance response and reversed the blockade of decapitation convulsions. However, animals pretreated with pargyline or desipramine before they received 5,7-DHT still demonstrated hyperactivity at 14 days of age equivalent to that observed in neonates that received only 5,7-DHT. Furthermore, a behavioral syndrome induced by 30 mg/kg of 5-hydroxytryptamine was markedly potentiated by all of the 5,7-DHT treatments which suggest that serotonin receptors were supersensitive.
向未成熟大鼠脑池内注射5,7-二羟基色胺（5,7-DHT）可使脑内去甲肾上腺素和5-羟色胺显著减少。伴随脑胺减少的是体重下降和行为改变。3日龄时用5,7-DHT处理后，14日龄时运动活性显著升高，但28日龄时降低。单独使用5,7-DHT还会导致穿梭箱回避反应的习得出现显著缺陷，并阻断断头后观察到的身体运动。在注射5,7-DHT前用优降宁或地昔帕明处理，可消除5,7-DHT对去甲肾上腺素能纤维的作用，同时增强5,7-DHT对脑5-羟色胺能纤维的作用。这些处理还将5,7-DHT对生长和回避反应习得的缺陷降至最低，并逆转了断头惊厥的阻断作用。然而，在接受5,7-DHT前用优降宁或地昔帕明预处理的动物在14日龄时仍表现出多动，与仅接受5,7-DHT的新生儿中观察到的情况相当。此外，30mg/kg 5-羟色胺诱导的行为综合征在所有5,7-DHT处理中均显著增强，这表明5-羟色胺受体超敏。
