Lolov Stephan, Zarzalanova Petya, Edrev George, Kyurkchiev Stanimir
Department of Molecular Immunology, Institute of Biology and Immunology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):279-83. doi: 10.1159/000075226.
Any kind of depressed systemic anti-measles reaction can lead to the induction of a local immune response in the inner ear and possibly to reactivation of bone turnover in this region.
Different dilutions of sera were tested for neutralizing activity against a constant viral concentration. The ability of measles virus to infect and replicate in the cell monolayer was detected by enumeration of living and growing cells with a colored reaction.
Virus-neutralizing activity in the sera of patients with confirmed otosclerosis was significantly weaker than in that of healthy controls. When age- and sex-matched pairs were compared, the neutralizing activity in the healthy counterpart was higher in 5 cases. Nearly complete viral neutralization was achieved with samples containing inactivated complement and in IgG-containing fractions, but not in immunoglobulin-depleted samples.
The present study is consistent with measles virus participation at least in the initiation of some cases of otosclerosis.
