Arnold W, Niedermeyer H P, Lehn N, Neubert W, Höfler H
Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany.
Acta Otolaryngol. 1996 Sep;116(5):705-9. doi: 10.3109/00016489609137910.
Histologic and immunohistochemical studies of otosclerotic lesions have shown that there is a chronic inflammatory reaction of the otic capsule with bone resorption resulting from vascular invasion accompanied by inflammatory cells. During the active lytic stage of otosclerosis, paramyxoviral structures have been identified by electron microscopy and measles virus antigen expression by immunohistochemistry. Recently, measles virus related sequences have been detected in tissue of otosclerotic lesions. Because the otosclerotic focus has a close relation to the perilymphatic space, the expression of measles virus antigens within it should represent an immunologic challenge to the immune system of the endolymphatic sac. In this study, measles virus specific antibodies were detected in all of the perilymph samples from 19 patients suffering from otosclerosis, and the relative amount of these IgG antibodies was much higher than in serum samples of the same patients or in perilymph of control patients. These findings support the hypothesis that measles viruses play an crucial role in the pathogenesis of otosclerosis.
耳硬化病变的组织学和免疫组织化学研究表明，耳囊存在慢性炎症反应，伴有血管侵入及炎性细胞的骨吸收。在耳硬化的活跃溶解期，通过电子显微镜已鉴定出副粘病毒结构，通过免疫组织化学检测到麻疹病毒抗原表达。最近，在耳硬化病变组织中检测到与麻疹病毒相关的序列。由于耳硬化病灶与外淋巴间隙关系密切，其中麻疹病毒抗原的表达应代表对内淋巴囊免疫系统的免疫挑战。在本研究中，在19例耳硬化患者的所有外淋巴样本中均检测到麻疹病毒特异性抗体，这些IgG抗体的相对量远高于同一患者的血清样本或对照患者的外淋巴。这些发现支持了麻疹病毒在耳硬化发病机制中起关键作用的假说。
