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难治性鼻窦炎并发免疫抑制:新型内源性防腐剂N-氯代牛磺酸的应用

Refractory rhinosinusitis complicating immunosuppression: application of N-chlorotaurine, a novel endogenous antiseptic agent.

作者信息

Gstöttner Michaela, Nagl Markus, Pototschnig Claus, Neher Andreas

机构信息

Department of Otorhinolaryngology, Leopold-Franzens University of Innsbruck, Innsbruck, Austria.

出版信息

ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):303-5. doi: 10.1159/000075231.

DOI:10.1159/000075231
PMID:14730189
Abstract

Severe infections are a frequent complication in immunosuppression following transplantations. In the case reported here, a heart-transplanted patient was treated for refractory rhinosinusitis with a combination of sinus surgery and rinsing with N-chlorotaurine (NCT). The daily rinse was well tolerated and effective. The combination of functional endonasal sinus surgery and topical treatment with NCT appeared effective and well tolerated in antibiotic-resistant sinusitis under immunosuppression.

摘要

严重感染是移植后免疫抑制过程中常见的并发症。在本文报道的病例中,一名心脏移植患者接受了鼻窦手术并使用N-氯代牛磺酸(NCT)冲洗治疗难治性鼻窦炎。每日冲洗耐受性良好且有效。在内镜鼻窦功能性手术与NCT局部治疗相结合的方法,对于免疫抑制状态下的耐药性鼻窦炎似乎有效且耐受性良好。

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N-chloramines, a promising class of well-tolerated topical anti-infectives.
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